Evidence map›Paper›PMID 35148233›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2022

Hypertension promotes microbial translocation and dysbiotic shifts in the fecal microbiome of nonhuman primates.

Ravichandra Vemuri, Alistaire Ruggiero, Jordyn M Whitfield, Greg O Dugan, J Mark Cline, Masha R Block, Hao Guo, Kylie Kavanagh

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Article
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  5. Article
  6. CD38bioRxiv : the preprint server for biology · 2025
    Article
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  14. Regulatory effect of gut microbes on blood pressure.Animal models and experimental medicine · 2022
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Ravichandra VemuriSection on Comparative Medicine, Department of Pathology, Wake Forest School of Medicine, Winston-Salem, North Carolina.ORCID 0000-0002-3238-426X
Alistaire RuggieroSection on Comparative Medicine, Department of Pathology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Jordyn M WhitfieldSection on Comparative Medicine, Department of Pathology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Greg O DuganSection on Comparative Medicine, Department of Pathology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
J Mark ClineSection on Comparative Medicine, Department of Pathology, Wake Forest School of Medicine, Winston-Salem, North Carolina.ORCID 0000-0003-4844-1238
Masha R BlockSection on Comparative Medicine, Department of Pathology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Hao GuoLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Kylie KavanaghSection on Comparative Medicine, Department of Pathology, Wake Forest School of Medicine, Winston-Salem, North Carolina.ORCID 0000-0001-8772-6186
Wake Forest University · USUniversity of North Carolina at Chapel Hill · USUniversity of Tasmania · AU

Funding

Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ian Michael Carroll · 1999 to 2026
$31.6M
PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Temitope O. Keku · 1985 to 2026
$30.5M
The Wake Forest Nonhuman Primate Radiation Survivor CohortU01AI150578 · NIAID · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI J. MARK CLINE · 2020 to 2026
$23.7M
Vervet Research Colony as a Biomedical ResourceP40OD010965 · OD · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Matthew Jorgensen · 2012 to 2026
$14.6M
TRAINING PROGRAM IN IMMUNOLOGY AND PATHOGENESIST32AI007401 · NIAID · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Martha Ann Alexander-Miller · 1991 to 2026
$4.4M
Laboratory Animal & Comparative Medicine TrainingT32OD010957 · OD · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI J. MARK CLINE · 2012 to 2026
$4.3M
Adipose Mitochondial Quality Control and Cardiovascular Function in Metabolically Healthy and Unhealthy Obese MonkeysR01HL142930 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KAVANAGH, KYLIE · 2019 to 2023
$3.4M
Summer Veterinary Student Research Fellows at Wake Forest UniversityT35OD010946 · OD · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Kylie Kavanagh · 2012 to 2026
$514k
HHS | National Institutes of Health (NIH) NIH UL1 TR004120HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) NIAID U19-A1067798NCATS NIH HHS UL1 TR001420NHLBI NIH HHS R01 HL142930NIAID NIH HHS T32 AI007401NIAID NIH HHS U01 AI150578NIDDK NIH HHS P30 DK034987NIDDK NIH HHS P30 DK056350NIH HHS P40 OD010965NIH HHS T32 OD010957NIH HHS T35 OD010946
6 · The paper itself

Abstract

Accumulating evidence indicates a link between gut barrier dysfunction and hypertension. However, it is unclear whether hypertension causes gut barrier dysfunction or vice versa and whether the gut microbiome plays a role. To understand this relationship, we first cross-sectionally examined 153 nonhuman primates [NHPs;

Indexed as

Gastrointestinal MicrobiomeHypertensionMicrobiotaAnimalsChlorocebus aethiopsDysbiosisFecesFemaleMaleblood pressurefecal microbiomegut barrier dysfunctionhypertensionmicrobial translocation

Identifiers

PMID35148233
PMCPMC8897002
OpenAlexW4211133389

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.