ArticleScience advances2022
Structural origins of cartilage shear mechanics.
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 38 citations in OpenAlex.
- A decoupling strategy toward spatiotemporal regulation and biomechanical transmission of sandwiched scaffold for osteochondral regeneration.Nature communications · 2026Article
- Assessing the micromechanical architecture of joint tissues with speckle rheological microscopy.Nature communications · 2026Article
- Shear Mechanics of Articular Cartilage and Cartilage-Inspired Materials.Annual review of condensed matter physics · 2026Article
- The osteochondral regeneration paradox: why biomimetic scaffolds are biologically superior but injectable systems dominate the clinic.RSC advances · 2026Review
- Delayed Lubricin Injection Improves Cartilage Repair Tissue Quality in an In Vivo Rabbit Osteochondral Defect Model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Decorin Promotes Nascent Proteoglycan Retention in Cartilage Matrix by Strengthening Collagen II-Aggrecan Integration.bioRxiv : the preprint server for biology · 2025Article
- Local shear properties of rabbit articular cartilage capture surface region mechanics of human, equine, and bovine tissue.Journal of biomechanics · 2025Article
- Biochemical and Biomechanical Properties of Scaffold-Free Hyaline Cartilage Generated Under Dynamic Conditions.International journal of molecular sciences · 2025Article
- Synovial joints were present in the common ancestor of jawed fish but lacking in jawless fish.PLoS biology · 2025Article
- Immune cells differentiation in osteoarthritic cartilage damage: friends or foes?Frontiers in immunology · 2025Review
- Decellularized extracellular matrix-based disease models for drug screening.Materials today. Bio · 2024Review
- Hyperelastic characterization reveals proteoglycans drive the nanoscale strain-stiffening response in hyaline cartilage.Journal of biomechanics · 2023Article
- Pre-glycation impairs gelation of high concentration collagen solutions.Journal of biomedical materials research. Part A · 2022Article
- Morphological Entanglement in Living Systems.Physical review. XArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Articular cartilage is a remarkable material able to sustain millions of loading cycles over decades of use outperforming any synthetic substitute. Crucially, how extracellular matrix constituents alter mechanical performance, particularly in shear, remains poorly understood. Here, we present experiments and theory in support of a rigidity percolation framework that quantitatively describes the structural origins of cartilage's shear properties and how they arise from the mechanical interdependence of the collagen and aggrecan networks making up its extracellular matrix. This framework explains that near the cartilage surface, where the collagen network is sparse and close to the rigidity threshold, slight changes in either collagen or aggrecan concentrations, common in early stages of cartilage disease, create a marked weakening in modulus that can lead to tissue collapse. More broadly, this framework provides a map for understanding how changes in composition throughout the tissue alter its shear properties and ultimate in vivo function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.