Evidence map›Paper›PMID 35148016›Full record

ArticleJournal of biomedical materials research. Part B, Applied biomaterials2022

Engineering a highly elastic bioadhesive for sealing soft and dynamic tissues.

Mahsa Ghovvati, Sevana Baghdasarian, Avijit Baidya, Jharana Dhal, Nasim Annabi

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomedical materials research. Part B, Applied biomaterials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mahsa GhovvatiDepartment of Chemical and Biomolecular Engineering, University of California - Los Angeles, Los Angeles, California, USA.
Sevana BaghdasarianDepartment of Chemical and Biomolecular Engineering, University of California - Los Angeles, Los Angeles, California, USA.
Avijit BaidyaDepartment of Chemical and Biomolecular Engineering, University of California - Los Angeles, Los Angeles, California, USA.ORCID 0000-0001-5215-2856
Jharana DhalDepartment of Chemical and Biomolecular Engineering, University of California - Los Angeles, Los Angeles, California, USA.
Nasim AnnabiDepartment of Chemical and Biomolecular Engineering, University of California - Los Angeles, Los Angeles, California, USA.ORCID 0000-0003-1879-1202
University of California, Los Angeles · US

Funding

Engineering highly elastic surgical sealants with hemostatic propertiesR01HL140618 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANNABI, NASIM, KHADEMHOSSEINI, ALI · 2018 to 2021
$2.8M
Engineering a naturally derived and highly adhesive surgical sealantR01EB023052 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANNABI, NASIM, KHADEMHOSSEINI, ALI · 2017 to 2022
$2.4M
NHLBI NIH HHS R01 HL140618NIBIB NIH HHS R01 EB023052
6 · The paper itself

Abstract

Injured tissues often require immediate closure to restore the normal functionality of the organ. In most cases, injuries are associated with trauma or various physical surgeries where different adhesive hydrogel materials are applied to close the wounds. However, these materials are typically toxic, have low elasticity, and lack strong adhesion especially to the wet tissues. In this study, a stretchable composite hydrogel consisting of gelatin methacrylol catechol (GelMAC) with ferric ions, and poly(ethylene glycol) diacrylate (PEGDA) was developed. The engineered material could adhere to the wet tissue surfaces through the chemical conjugation of catechol and methacrylate groups to the gelatin backbone. Moreover, the incorporation of PEGDA enhanced the elasticity of the bioadhesives. Our results showed that the physical properties and adhesion of the hydrogels could be tuned by changing the ratio of GelMAC/PEGDA. In addition, the in vitro toxicity tests confirmed the biocompatibility of the engineered bioadhesives. Finally, using an ex vivo lung incision model, we showed the potential application of the developed bioadhesives for sealing elastic tissues.

Indexed as

GelatinHydrogelsAdhesivesCatecholsMethacrylatesPolyethylene GlycolsAdhesivesCatecholsGelatinHydrogelsMethacrylatesPolyethylene Glycolsadhesiveelastichydrogelpoly(ethylene glycol) diacrylatesealant

Identifiers

PMID35148016
PMCPMC9106862
OpenAlexW4211015295

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.