Evidence map›Paper›PMID 35147989›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2022

Nucleotide receptors mediate protection against neonatal sepsis and meningitis caused by alpha-hemolysin expressing Escherichia coli K1.

Catherine A Chambers, Alexis S Dadelahi, Charles R Moley, Rachel M Olson, Catherine M Logue, Jerod A Skyberg

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Case Study: Illuminating the Nanoscale World of Microbiology.Methods in molecular biology (Clifton, N.J.) · 2026
    Review
  2. Advancing Understanding ofMicroorganisms · 2025
    Article
  3. Targeting P2X Receptors-Current Progress in Sepsis.International journal of inflammation · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Catherine A ChambersDepartment of Veterinary Pathobiology, University of Missouri, Columbia, Missouri, USA.
Alexis S DadelahiDepartment of Veterinary Pathobiology, University of Missouri, Columbia, Missouri, USA.
Charles R MoleyDepartment of Veterinary Pathobiology, University of Missouri, Columbia, Missouri, USA.
Rachel M OlsonDepartment of Veterinary Pathobiology, University of Missouri, Columbia, Missouri, USA.
Catherine M LogueDepartment of Population Heath, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA.
Jerod A SkybergDepartment of Veterinary Pathobiology, University of Missouri, Columbia, Missouri, USA.ORCID https://orcid.org/0000-0002-2337-908X
University of Missouri · USUniversity of Georgia · US

Funding

Postdoctoral Training in Comparative MedicineT32OD011126 · OD · UNIVERSITY OF MISSOURI-COLUMBIA · PI Elizabeth C Bryda, Aaron Ericsson · 2012 to 2026
$3.4M
NIH HHS T32 OD011126
6 · The paper itself

Abstract

Neonatal meningitis-associated Escherichia coli (NMEC) is among the leading causes of bacterial meningitis and sepsis in newborn infants. Several virulence factors have been identified as common among NMEC, and have been shown to play an important role in the development of bacteremia and/or meningitis. However, there is significant variability in virulence factor expression between NMEC isolates, and relatively little research has been done to assess the impact of variable virulence factor expression on immune cell activation and the outcome of infection. Here, we investigated the role of NMEC strain-dependent P2X receptor (P2XR) signaling on the outcome of infection in neonatal mice. We found that alpha-hemolysin (HlyA)-expressing NMEC (HlyA

Indexed as

AnimalsCells, CulturedEscherichia coli K12Escherichia coli ProteinsHemolysin ProteinsInflammasomesMacrophagesMeningitis, Escherichia coliMiceMice, Inbred C57BLNeonatal SepsisReceptors, Purinergic P2XEscherichia coli ProteinsHemolysin ProteinsHlya protein, E coliInflammasomesReceptors, Purinergic P2Xhemolysininflammasomeneonatal immunityneonatal meningitis-associated Escherichia coli (NMEC)NLRP3nucleotide receptor

Identifiers

PMID35147989
PMCPMC12433237
OpenAlexW4211111710

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.