SynthesisJournal of endocrinological investigation2022
Clinical and radiological presentation of parasellar ectopic pituitary adenomas: case series and systematic review of the literature.
Synthesis in Journal of endocrinological investigation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Ectopic ACTH-Secreting Pituitary Adenoma of the Maxillary Sinus: A Rare Cause of Cushing's Syndrome.Turkish archives of otorhinolaryngology · 2026Article
- Hyperprolactinemia caused by extra-pituitary prolactin secretion: a systematic review.Endocrine connections · 2025Article
- Chinese expert consensus on imaging examination and diagnosis of nasal cavity and paranasal sinus tumors.Frontiers in oncology · 2025Review
- Ectopic pituitary adenoma in sphenoid sinus: a case presentation.Quantitative imaging in medicine and surgery · 2024Article
- [Ectopic pituitary tumor of sphenoid sinus: a case report].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024Article
- Clival ectopic pituitary prolactinoma was successfully managed by transsphenoidal surgery: A rare case report.Clinical case reports · 2023Article
- Prediction of intraoperative cerebrospinal fluid leaks in endoscopic endonasal transsphenoidal pituitary surgery based on a deep neural network model trained with MRI images: a pilot study.Frontiers in neuroscience · 2023Article
- Review
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Authors and funding
14 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeParasellar ectopic pituitary adenomas (pEPAs) are extremely rare tumors located out of the sella turcica. PEPAs are heterogeneous entities in terms of anatomical localization and secretion of anterior pituitary hormones.
methodsMulticenter retrospective study. Clinical charts' consultation of patients diagnosed with parasellar lesions, to identify all subjects fulfilling the diagnostic criteria of parasellar EPAs. Systematic review of the literature focused on the medical management of prolactin-secreting pEPAs and on the prevalence of radiological bone invasion in pEPAs.
resultsWe identified four cases of pEPAs: (1) 54-year-old female with a prolactin-secreting suprasellar EPA successfully treated with cabergoline; (2) 74-year-old male with a non-functioning EPA of the sphenoidal sinus treated with endoscopic transsphenoidal surgery; (3) 75-year-old female with a giant lesion of the skull base (maximum diameter 7.2 cm) diagnosed as a non-functioning EPA after biopsy; (4) 49-year-old male with a silent corticotroph EPA of the sphenoidal sinus and clivus. Three out of four cases had radiological evidence of invasion of the surrounding bone structures. A systematic review of the literature highlighted that medical therapy can be effective in prolactin-secreting pEPAs. Overall, we found mention of local invasiveness in 65/147 cases (44.2%), confirmed by radiological signs of bone invasion/erosion.
conclusionOur experience confirms the heterogeneity of pEPAs in terms of clinical and radiological presentation, as well as hormone secretion. PEPAs show a high frequency of radiological bone invasion, though similar to that of sellar pituitary adenomas. Although extremely rare, pEPAs need to be considered in the differential diagnosis of parasellar lesions.
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