Evidence map›Paper›PMID 35147861›Full record

ArticleMolecular diversity2022

Antioxidant and cytotoxic activities of selected salicylidene imines: experimental and computational study.

Jovica Branković, Marios G Krokidis, Irini Dousi, Kyriakos Papadopoulos, Zorica D Petrović, Vladimir P Petrović

Abstract read
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In one paragraph

Article in Molecular diversity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jovica BrankovićDepartment of Chemistry, Faculty of Science, University of Kragujevac, 12 Radoja Domanovića, 34000, Kragujevac, Serbia.
Marios G KrokidisInstitute of Nanoscience and Nanotechnology, National Center for Scientific Research "Demokritos", 15341 Agia Paraskevi Attikis, Athens, Greece. m.krokidis@inn.demokritos.gr.
Irini DousiInstitute of Nanoscience and Nanotechnology, National Center for Scientific Research "Demokritos", 15341 Agia Paraskevi Attikis, Athens, Greece.
Kyriakos PapadopoulosInstitute of Nanoscience and Nanotechnology, National Center for Scientific Research "Demokritos", 15341 Agia Paraskevi Attikis, Athens, Greece.
Zorica D PetrovićDepartment of Chemistry, Faculty of Science, University of Kragujevac, 12 Radoja Domanovića, 34000, Kragujevac, Serbia.
Vladimir P PetrovićDepartment of Chemistry, Faculty of Science, University of Kragujevac, 12 Radoja Domanovića, 34000, Kragujevac, Serbia. vladimir.petrovic@pmf.kg.ac.rs.ORCID http://orcid.org/0000-0002-1904-368X

Funding

Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja 451-03-9/2021-14/200122
6 · The paper itself

Abstract

Selected salicylidene imines were evaluated for their antioxidant and cytotoxic potentials. Several of them exerted potent scavenging capacity towards ABTS radical and hydrogen peroxide. The insight into the preferable antioxidative mechanism was reached employing density functional theory. In the absence of free radicals, the SPLET mechanism is dominant in polar surroundings, while HAT is prevailing in a non-polar environment. The results obtained for the reactions of the most active compounds with some medically relevant radicals pointed out competition between HAT and SPLET mechanisms. The assessment of their cytotoxic properties revealed inhibition of ER-a human breast adenocarcinoma cells or estrogen-independent prostate cancer cells. Molecular docking study with the cyclooxygenase (COX) 2 enzyme was performed to examine the most probable bioactive conformations and possible interactions between the tested derivatives and COX-2 binding pocket.

Indexed as

AntioxidantsIminesFree RadicalsHumansMolecular Docking SimulationAntioxidantsFree RadicalsIminesAntioxidant activityComputational studyCytotoxic activityDensity functional theoryMolecular dockingSalicylidene imines

Identifiers

PMID35147861

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.