Evidence map›Paper›PMID 35147845›Full record

ArticleBiotechnology letters2022

Larvicidal activity against Aedes aegypti and molecular docking studies of compounds extracted from the endophytic fungus Aspergillus sp. isolated from Bertholletia excelsa Humn. & Bonpl.

Inana F Araújo, Victor Hugo de S Marinho, Iracirema da S Sena, Jhone M Curti, Ryan da S Ramos, Ricardo M A Ferreira, Raimundo N P Souto, Irlon M Ferreira

Abstract read
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In one paragraph

Article in Biotechnology letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Toxicity and Anti-inflammatory Effects ofAnti-inflammatory & anti-allergy agents in medicinal chemistry · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Inana F AraújoBiocatalysis and Applied Organic Synthesis Laboratory, Collegiate of Chemistry, Federal University of Amapá, Rod. JK, KM 02, Macapá, Amapá, 68902-280, Brazil.
Victor Hugo de S MarinhoBiocatalysis and Applied Organic Synthesis Laboratory, Collegiate of Chemistry, Federal University of Amapá, Rod. JK, KM 02, Macapá, Amapá, 68902-280, Brazil.
Iracirema da S SenaBiocatalysis and Applied Organic Synthesis Laboratory, Collegiate of Chemistry, Federal University of Amapá, Rod. JK, KM 02, Macapá, Amapá, 68902-280, Brazil.
Jhone M CurtiBiocatalysis and Applied Organic Synthesis Laboratory, Collegiate of Chemistry, Federal University of Amapá, Rod. JK, KM 02, Macapá, Amapá, 68902-280, Brazil.
Ryan da S RamosLaboratory of Modeling and Computational Chemistry, Department of Biological and Health Sciences, Federal University of Amapá, Macapá, AP, 68902-280, Brazil.
Ricardo M A FerreiraArthropod Laboratory, Collegiate of Biology, Federal University of Amapá, Rod. JK, KM 02, Macapá, Amapá, 68902-280, Brazil.
Raimundo N P SoutoArthropod Laboratory, Collegiate of Biology, Federal University of Amapá, Rod. JK, KM 02, Macapá, Amapá, 68902-280, Brazil.
Irlon M FerreiraBiocatalysis and Applied Organic Synthesis Laboratory, Collegiate of Chemistry, Federal University of Amapá, Rod. JK, KM 02, Macapá, Amapá, 68902-280, Brazil. irlon.ferreira@gmail.com.ORCID http://orcid.org/0000-0002-4517-0105

Funding

Fundação de Amparo à Pesquisa do Estado do Amapá 34568.515.22257.28052017
6 · The paper itself

Abstract

Endophytic fungi are microorganisms capable of colonizing the interior of plant tissues without causing damage to them. The study of the secondary metabolites produced by their vast biodiversity fungal is relevant for the discovery of new products for biotechnological and agrochemical applications. In addition, extract of the endophytic fungus Aspergillus sp., isolated from the almonds of Bertholletia excelsa Humn & Bonlp collected in the Brazilian Amazon, oviposition deterrent, and larvicidal activity of against Aedes aegypti. In the oviposition deterrence test was observed that females able to lay eggs preferred the control oviposition sites (46.6%). Furthermore, the extract showed larvicidal activity with LC50 26.86 µg/mL at 24 h and 18.75 µg/mL at 48 h. Molecular docking studies showed the compound Aspergillol B a potent larvicide by to inhibit the acetylcholinesterase enzyme (- 7.74 kcal/mol). These results indicate that compounds from secondary metabolites of Aspergillus sp., isolated from almonds of B. excelsa, are useful biological potential against vectors A. aegypti.

Indexed as

AedesBertholletiaInsecticidesAcetylcholinesteraseAnimalsAspergillusFemaleLarvaMolecular Docking SimulationMosquito VectorsPlant ExtractsAcetylcholinesteraseInsecticidesPlant ExtractsAcetylcholinesteraseAmazonian biodiversityAspergillol BOviposition

Identifiers

PMID35147845

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.