Evidence map›Paper›PMID 35147837›Full record

ArticleMolecular imaging and biology2022

EGFR-Targeted ImmunoPET of UMUC3 Orthotopic Bladder Tumors.

Tran T Hoang, Komal Mandleywala, Tara Viray, Kel Vin Tan, Jason S Lewis, Patricia M R Pereira

Open access · greenAbstract read
In one paragraph

Article in Molecular imaging and biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Immuno-PET Imaging of EGFR withMolecular pharmaceutics · 2024
    Article
  4. Review
  5. Review
  6. PET Imaging in Bladder Cancer: An Update and Future Direction.Pharmaceuticals (Basel, Switzerland) · 2023
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Tran T HoangDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Komal MandleywalaDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Tara VirayDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Kel Vin TanDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Jason S LewisDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA. lewisj2@mskcc.org.
Patricia M R PereiraDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA. ribeiropereirap@wustl.edu.
Memorial Sloan Kettering Cancer Center · USCornell University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
Leveraging Pb-203/212 for the Theranostic Imaging and Therapy of Prostate CancerR35CA232130 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S. · 2019 to 2025
$8.2M
Improving radiolabeled imaging and targeting of HER2 positive EG cancers using lovastatinR01CA244233 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI JANJIGIAN, YELENA Y, LEWIS, JASON S. · 2021 to 2025
$3.4M
Predoctoral Training in Pharmacological SciencesT32GM141949 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Kristen Elizabeth Pleil · 2021 to 2026
$2.5M
NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA244233NCI NIH HHS R35 CA232130NIGMS NIH HHS T32 GM141949
6 · The paper itself

Abstract

purposeImmuno-positron emission tomography (immunoPET) combines the specificity of an antibody with the sensitivity of PET to image dysregulated pathways in cancer. This study examines the performance of immunoPET using the radioimmunoconjugate [ PROCEDURES: Expression and quantification of EGFR receptors were confirmed in four different BCa cell lines. Binding assays validated [

results[

conclusionThe preclinical data presents a proof of concept for utilizing EGFR-targeted immunoPET to image BCa with altered EGFR protein levels.

Indexed as

ImmunoconjugatesUrinary Bladder NeoplasmsAnimalsCell Line, TumorErbB ReceptorsHumansMicePanitumumabPositron-Emission TomographyTissue DistributionZirconiumEGFR protein, humanErbB ReceptorsImmunoconjugatesPanitumumabZirconiumBladder CancerEGFRImmunoPET

Identifiers

PMID35147837
PMCPMC10187976
OpenAlexW4211060576

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.