Evidence map›Paper›PMID 35147814›Full record

SynthesisEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2022

Rapid diagnostic test (Leptocheck-WB) for detection of acute leptospirosis: a meta-analysis of diagnostic accuracy.

Siau Ek Hwee, Norah Htet Htet, Cho Naing, Wong Siew Tung, Joon Wah Mak

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Development of a new accurate lateral flow immunoassay for diagnosis of human leptospirosis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Siau Ek HweeInternational Medial University, Kuala Lumpur, Malaysia.
Norah Htet Htet *International Medial University, Kuala Lumpur, Malaysia.ORCID http://orcid.org/0000-0003-2143-8629
Cho NaingDivision of Tropical Health and Medicine, James Cook University, Queensland, Australia. cho3699@gmail.com.ORCID http://orcid.org/0000-0003-3425-7149
Wong Siew Tung *International Medial University, Kuala Lumpur, Malaysia.ORCID http://orcid.org/0000-0003-1320-2632
Joon Wah MakInternational Medial University, Kuala Lumpur, Malaysia.ORCID http://orcid.org/0000-0002-2538-0797
IMU University · MYAustralian Institute of Tropical Health and Medicine · AU

Funding

International Medical University ID: 353/2020
6 · The paper itself

Abstract

The majority of leptospirosis is subclinical or mild self-limiting systemic illness. A rapid and accurate diagnostic test for the detection of leptospirosis is essential to prevent disease progression from acute non-severe illness to potentially fatal infection. Rapid diagnostic tests (RDTs) recognized as point-of-care (PoC) tests may support clinical decision-making in resource-poor settings. We aimed to assess the accuracy of PoC (Leptocheck-WB) for the detection of acute leptospirosis by meta-analysis of data from eligible studies. This study adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis for Diagnostic Test Accuracy (PRISMA-DTA) guideline. The pooling of data was done only when there were two or more studies that used a particular type of reference test. A total of ten studies (n = 5369) were identified. The majority (70%) were from the Asian region. Using microscopic agglutination test (MAT) as reference test, the pooled sensitivity (0.75, 95% CI: 0.64 to 0.84, 10 studies, I

Indexed as

Diagnostic Tests, RoutineLeptospirosisAntibodies, BacterialEnzyme-Linked Immunosorbent AssayHumansSensitivity and SpecificityAntibodies, BacterialLeptocheck-WBLeptospirosisMeta-analysisTest accuracy

Identifiers

PMID35147814
OpenAlexW4211223294

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.