Evidence map›Paper›PMID 35147617›Full record

ArticleDalton transactions (Cambridge, England : 2003)2022

Synthesis, physicochemical characterization and neuroprotective evaluation of novel 1-hydroxypyrazin-2(1

Frank W Lewis, Kathleen Bird, Jean-Philippe Navarro, Rawa El Fallah, Jeremy Brandel, Véronique Hubscher-Bruder, Andrew Tsatsanis, James A Duce, David Tétard, Samuel Bourne and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Dalton transactions (Cambridge, England : 2003), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. 1-Hydroxy-2(1Molecules (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Frank W LewisDepartment of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, Tyne and Wear NE1 8ST, UK. frank.lewis@northumbria.ac.uk.ORCID http://orcid.org/0000-0003-3176-8162
Kathleen BirdDepartment of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, Tyne and Wear NE1 8ST, UK. frank.lewis@northumbria.ac.uk.
Jean-Philippe NavarroDepartment of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, Tyne and Wear NE1 8ST, UK. frank.lewis@northumbria.ac.uk.
Rawa El FallahUniversité de Strasbourg, CNRS, IPHC UMR 7178, F-67000 Strasbourg, France. jbrandel@unistra.fr.
Jeremy BrandelUniversité de Strasbourg, CNRS, IPHC UMR 7178, F-67000 Strasbourg, France. jbrandel@unistra.fr.
Véronique Hubscher-BruderUniversité de Strasbourg, CNRS, IPHC UMR 7178, F-67000 Strasbourg, France. jbrandel@unistra.fr.ORCID http://orcid.org/0000-0001-5459-7197
Andrew TsatsanisSchool of Biomedical Sciences, The Faculty of Biological Sciences, University of Leeds, Leeds, West Yorkshire LS2 9JT, UK.
James A DuceSchool of Biomedical Sciences, The Faculty of Biological Sciences, University of Leeds, Leeds, West Yorkshire LS2 9JT, UK.
David TétardDepartment of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, Tyne and Wear NE1 8ST, UK. frank.lewis@northumbria.ac.uk.ORCID http://orcid.org/0000-0002-7474-1421
Samuel BourneSchool of Life Sciences, University of Sussex, Falmer, Sussex BN1 9PH, UK. I.S.Pienaar@sussex.ac.uk.
Mahmoud MainaSchool of Life Sciences, University of Sussex, Falmer, Sussex BN1 9PH, UK. I.S.Pienaar@sussex.ac.uk.
Ilse S PienaarSchool of Life Sciences, University of Sussex, Falmer, Sussex BN1 9PH, UK. I.S.Pienaar@sussex.ac.uk.ORCID http://orcid.org/0000-0001-6507-9563
Northumbria University · GBCentre National de la Recherche Scientifique · FRUniversity of Sussex · GBUniversity of Leeds · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Iron dysregulation, dopamine depletion, cellular oxidative stress and α-synuclein protein mis-folding are key neuronal pathological features seen in the progression of Parkinson's disease. Iron chelators endowed with one or more therapeutic modes of action have long been suggested as disease modifying therapies for its treatment. In this study, novel 1-hydroxypyrazin-2(1

Indexed as

Cell SurvivalIron Chelating AgentsNeuroprotective AgentsParkinson DiseaseAntioxidantsCell Line, TumorHumansLigandsOxidopamineAntioxidantsIron Chelating AgentsLigandsNeuroprotective AgentsOxidopamine

Identifiers

PMID35147617
PMCPMC8886574
OpenAlexW4210976969

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.