ArticleeLife2022
Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin.
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Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
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Who cites it
44 citing papers in PubMed, 65 citations in OpenAlex.
- Genetic influences on haematopoiesis.Nature reviews. Genetics · 2026Review
- In vivo genome editing of human haematopoietic stem cells for treatment of blood disorders using mRNA delivery.Nature biomedical engineering · 2026Article
- Functional correction and genome integrity with duplex base editing of β-thalassemic hematopoietic stem cells.Genome biology · 2026Article
- CRISPR-based therapeutic genome editing for inherited blood disorders.Nature reviews. Drug discovery · 2025Review
- Article
- Review
- Multiplex base editing of BCL11A regulatory elements to treat sickle cell disease.Cell reports. Medicine · 2025Article
- Genetic Engineering in Hematopoietic Stem Cells for β-Hemoglobinopathies Treatment: Advances, Challenges, and Clinical Translation.International journal of hematology-oncology and stem cell research · 2025Review
- Peptide-enabled ribonucleoprotein delivery for CRISPR engineering (PERC) in primary human immune cells and hematopoietic stem cells.Nature protocols · 2025Review
- Removal of promoter CpG methylation by epigenome editing reverses HBG silencing.Nature communications · 2025Article
- Multiplex base editing to protect from CD33 directed drugs for immune and gene therapy.Nature communications · 2025Article
- The 2SP Site Mutation in the Bovine Natural Resistance-Associated Macrophage 1 Promoter Exhibits Antituberculosis Potential.International journal of molecular sciences · 2025Article
- Review
- Enhanced fetal hemoglobin production via dual-beneficial mutation editing of the HBG promoter in hematopoietic stem and progenitor cells for β-hemoglobinopathies.Stem cell research & therapy · 2024Article
- Resolving the chromatin impact of mosaic variants with targeted Fiber-seq.Genome research · 2024Article
- Editing of homologous globin genes by nickase-deficient base editor mitigates large intergenic deletions in HSPCs.Molecular therapy. Nucleic acids · 2024Article
- Transcriptional regulators of fetal hemoglobin.Hematology, transfusion and cell therapy · 2024Review
- Review
- CRISPR technology in human diseases.MedComm · 2024Review
- PAM-flexible Engineered FnCas9 variants for robust and ultra-precise genome editing and diagnostics.Nature communications · 2024Article
Corrections and comments
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Authors and funding
25 authors at 8 institutions in 4 countries.
Nithin Sam RaviCentre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.ORCID 0000-0002-8063-6935
Beeke WienertInnovative Genomics Institute, University of California, Berkeley, Berkeley, United States.
Stacia K WymanInnovative Genomics Institute, University of California, Berkeley, Berkeley, United States.
Henry William BellSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia.ORCID 0000-0003-4677-8208
Anila GeorgeCentre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.ORCID 0000-0002-6016-976X
Gokulnath MahalingamCentre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.
Jonathan T VuInnovative Genomics Institute, University of California, Berkeley, Berkeley, United States.ORCID 0000-0002-4950-7967
Kirti PrasadCentre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.
Bhanu Prasad BandlamudiCentre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.
Nivedhitha DevarajuCentre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.
Vignesh RajendiranCentre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.
Nazar SyedbashaCentre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.
Aswin Anand PaiSree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India.
Yukio NakamuraCell Engineering Division, RIKEN BioResource Center, Ibaraki, Japan.
Ryo KuritaResearch and Development Department, Central Blood Institute Blood Service Headquarters, Japanese Red Cross Society, Japan, Tokyo, Japan.
Muthuraman NarayanasamyCentre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.
Poonkuzhali BalasubramanianSree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India.
Saravanabhavan ThangavelCentre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.
Srujan MarepallyCentre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.
Shaji R VelayudhanCentre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.
Alok SrivastavaCentre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.
Mark A DeWittInnovative Genomics Institute, University of California, Berkeley, Berkeley, United States.
Merlin CrossleySchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia.
Jacob E CornInnovative Genomics Institute, University of California, Berkeley, Berkeley, United States.ORCID 0000-0002-7798-5309
Kumarasamypet M MohankumarCentre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.ORCID 0000-0001-9407-1800
Christian Medical College, Vellore · INInnovative Genomics Institute · USManipal Academy of Higher Education · INUNSW Sydney · AUGladstone Institutes · USJapanese Red Cross Society, Japan · JPRIKEN BioResource Research Center · JPUniversity of California, Los Angeles · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
Naturally occurring point mutations in the
Indexed as
CRISPR-Cas SystemsAdenineAnemia, Sickle Cellbeta-Globinsbeta-ThalassemiaCell LineClustered Regularly Interspaced Short Palindromic RepeatsCytosineFetal Hemoglobingamma-GlobinsGene EditingHematopoietic Stem CellsHumansPoint MutationPromoter Regions, GeneticAdeninebeta-GlobinsCytosineFetal Hemoglobingamma-Globinsbase editingbeta hemoglobinopathiesbeta-hemoglobinopathiesbeta-thalassemiacd34+ hspcschromosomescrispr/cas9CRISPR/Cas9fetal hemoglobingene expressiongeneticsgenomicsglobin regulationhbgpromoterhpfh mutationsHPFH mutationslarge deletionssickle cell disease
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.