ArticleEndocrinology, diabetes & metabolism2022
Longitudinal changes in blood biomarkers and their ability to predict type 2 diabetes mellitus-The Tromsø study.
Article in Endocrinology, diabetes & metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Temporal changes in per and polyfluoroalkyl substances and their associations with type 2 diabetes.Scientific reports · 2025Article
- Characterizing trajectories of diabetes-related health parameters before diabetes diagnosis in diabetes subtypes: analysis of a 20-year long prospective cohort study in Sweden.Cardiovascular diabetology · 2025Article
- Article
- Diabetes Modulates Iodothyronine Deiodinase 2 Expression in the Mouse Retina: A Role for Thyroid Hormone in the Pathogenesis of Diabetic Retinopathy.Investigative ophthalmology & visual science · 2023Article
- Artificial intelligence with temporal features outperforms machine learning in predicting diabetes.PLOS digital health · 2023Article
- Longitudinal changes in vitamin D concentrations and the association with type 2 diabetes mellitus: the Tromsø Study.Acta diabetologica · 2023Article
- Predictive model of diabetes mellitus in patients with idiopathic inflammatory myopathies.Frontiers in endocrinology · 2023Article
- Longitudinal changes in blood biomarkers and their ability to predict type 2 diabetes mellitus-The Tromsø study.Endocrinology, diabetes & metabolism · 2022Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIdentification of individuals at high risk of developing type 2 diabetes mellitus (T2DM) is important for early prevention of the disease. Once T2DM is established, it is difficult to treat and is associated with cardiovascular complications and increased mortality. We aimed to describe pre- and post-diagnostic changes in blood biomarker concentrations over 30 years in individuals with and without T2DM, and to determine the predictive potential of pre-diagnostic blood biomarkers.
methodsThis nested case-control study included 234 participants in the Tromsø Study who gave blood samples at five time points between 1986 and 2016: 130 did not develop T2DM and were used as controls; 104 developed T2DM after the third time point and were included as cases. After stratifying by sex, we investigated changes in pre- and post-diagnostic concentrations of lipids, thyroid hormones, HbA
resultsCases and controls experienced different longitudinal changes in lipids, free T
conclusionThere were clear differences in blood biomarker concentrations between cases and controls throughout the study, and several blood biomarkers were associated with T2DM. Selected blood biomarkers (lipids, HbA
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