ArticleEuropean journal of neurology2022
Risk factors, neuroimaging correlates and prognosis of the motoric cognitive risk syndrome: A population-based comparison with mild cognitive impairment.
Article in European journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Motoric Cognitive Risk Syndrome and the Risk of Incident Dementia: A Systematic Review and Meta-Analysis of Cohort Studies.Gerontology · 2024Pooled it
- Linking dementia prodromes and cancer through motor function impairment: the Rotterdam-Study.BMC geriatrics · 2026Article
- Associations Between Smartphone-Based Finger Tapping and Cognitive Performance in Older Adults: Observational Study.Journal of medical Internet research · 2026Observational
- The relationship between motoric cognitive risk syndrome and all-cause mortality in older people: findings from CHARLS 2011-2023.Archives of public health = Archives belges de sante publique · 2025Article
- Greater White Matter Hyperintensities and More Severe Cognitive Dysfunction in Mild Cognitive Impairment With Motoric Cognitive Risk Syndrome.Journal of Korean medical science · 2025Article
- Motoric Cognitive Risk Syndrome and Risk of Cardiovascular Disease: A Population-Based Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Clinical, biological, and neuroimaging profiles for motoric cognitive risk syndrome in older adults: The MIND-China study.Journal of internal medicine · 2025Article
- Combined impact of neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) and cognitive function on all-cause mortality in older adults: a population-based study.Lipids in health and disease · 2025Article
- Evaluation criteria for diagnosing motoric cognitive risk syndrome: a scoping review.Dementia & neuropsychologia · 2025Review
- Family history of dementia and brain health in childhood and middle age: a prospective community-based study.European journal of epidemiology · 2024Article
- Article
- [Motoric cognitive risk syndrome-Setting the course for dementia prevention?]Der Nervenarzt · 2023Review
- New horizons in cognitive and functional impairment as a consequence of cerebral small vessel disease.Age and ageing · 2023Article
- Association of Motoric Cognitive Risk Syndrome with Sarcopenia and Systemic Inflammation in Pre-Frail Older Adults.Brain sciences · 2023Article
- Prevalence and predictors of Motoric Cognitive Risk syndrome in a community-dwelling older Scottish population: A longitudinal observational study.International journal of geriatric psychiatry · 2022Observational
- Risk factors, neuroimaging correlates and prognosis of the motoric cognitive risk syndrome: A population-based comparison with mild cognitive impairment.European journal of neurology · 2022Article
- Associations between blood-based biomarkers of Alzheimer's disease with cognition in motoric cognitive risk syndrome: A pilot study using plasma Aβ42 and total tau.Frontiers in aging neuroscience · 2022Article
- Motoric cognitive risk syndrome in people with multiple sclerosis: prevalence and correlations with disease-related factors.Therapeutic advances in neurological disorders · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThis study was undertaken to compare risk factors, neuroimaging characteristics and prognosis between two clinical prodromes of dementia, namely, the motoric cognitive risk syndrome (MCRS) and mild cognitive impairment (MCI).
methodsBetween 2009 and 2015, dementia-free participants of the population-based Rotterdam Study were classified with a dementia prodrome if they had subjective cognitive complaints and scored >1 SD below the population mean of gait speed (MCRS) or >1.5 SD below the population mean of cognitive test scores (MCI). Using multinomial logistic regression models, we determined cross-sectional associations of risk factors and structural neuroimaging markers with MCRS and MCI, followed by subdistribution hazard models, to determine risk of incident dementia until 2016.
resultsOf 3025 included participants (mean age = 70.4 years, 54.7% women), 231 had MCRS (7.6%), 132 had MCI (4.4%), and 62 (2.0%) fulfilled criteria for both. Although many risk factors were shared, a higher body mass index predisposed to MCRS, whereas male sex and hypercholesterolemia were associated with MCI only. Gray matter volumes, hippocampal volumes, white matter hyperintensities, and structural white matter integrity were worse in both MCRS and MCI. During a mean follow-up of 3.9 years, 71 individuals developed dementia and 200 died. Five-year cumulative risk of dementia was 7.0% (2.5%-11.5%) for individuals with MCRS, versus 13.3% (5.8%-20.8%) with MCI and only 2.3% (1.5%-3.1%) in unaffected individuals.
conclusionsMCRS is associated with imaging markers of neurodegeneration and risk of dementia, even in the absence of MCI, highlighting the potential of motor function assessment in early risk stratification for dementia.
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