ArticleeLife2022
STIM1-dependent peripheral coupling governs the contractility of vascular smooth muscle cells.
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Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
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Who cites it
23 citing papers in PubMed, 29 citations in OpenAlex.
- Hypercapnia enhances airway smooth muscle contractility via STIM1-dependent Ca2+ signaling.JCI insight · 2026Article
- The nonexcitable smooth muscle: remodeling the smooth muscle ion transport toolkit in disease.Physiological reviews · 2026Review
- Potassium channels in vascular smooth muscle cells.Physiological reviews · 2026Review
- Pacemaking in the lymphatic system.The Journal of physiology · 2026Review
- Regulation of Collecting Lymphatic Vessel Contractile Function by TRPV4 Channels.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- Loss of STIM2, but not of STIM1, drives colorectal cancer metastasis through metabolic reprogramming and the ATF4 ER stress pathway.Science signaling · 2025Article
- Artificial light at night affects the daily profile of pulse pressure and protein expression in the thoracic aorta of rats.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Vascular polycystin proteins in health and disease.Microcirculation (New York, N.Y. : 1994) · 2024Review
- Cardiovascular perspectives of the TRP channel polycystin 2.The Journal of physiology · 2024Article
- IP3R1 underlies diastolic ANO1 activation and pressure-dependent chronotropy in lymphatic collecting vessels.The Journal of general physiology · 2023Article
- Impaired intracellular CaScience signaling · 2023Article
- Diabetic Endothelial Cell Glycogen Synthase Kinase 3β Activation Induces VCAM1 Ectodomain Shedding.International journal of molecular sciences · 2023Article
- Uncoupling of CaProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Sarsasapogenin blocks ox-LDL-stimulated vascular smooth muscle cell proliferation, migration, and invasion through suppressing STIM1 expression.Cardiovascular diagnosis and therapy · 2023Article
- Vascular mechanotransduction.Physiological reviews · 2023Review
- Endoplasmic Reticulum-Plasma Membrane Junctions as Sites of Depolarization-Induced CaAnnual review of physiology · 2023Review
- Acid-sensing ion channel 1a activates IKCa/SKCa channels and contributes to endothelium-dependent dilation.The Journal of general physiology · 2023Article
- Endothelial cell TRPA1 activity exacerbates cerebral hemorrhage during severe hypertension.Frontiers in molecular biosciences · 2023Article
- Mechanisms and physiological implications of cooperative gating of clustered ion channels.Physiological reviews · 2022Review
- Functionally linked potassium channel activity in cerebral endothelial and smooth muscle cells is compromised in Alzheimer's disease.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Vivek Krishnan *Department of Pharmacology, Center for Molecular and Cellular Signaling in the Cardiovascular System, University of Nevada, Reno, United States.ORCID 0000-0001-5064-4910
Sher Ali *Department of Pharmacology, Center for Molecular and Cellular Signaling in the Cardiovascular System, University of Nevada, Reno, United States.
Albert L Gonzales *Department of Physiology and Cell Biology, Center for Molecular and Cellular Signaling 18 in the Cardiovascular System, University of Nevada, Reno, United States.
Pratish Thakore *Department of Pharmacology, Center for Molecular and Cellular Signaling in the Cardiovascular System, University of Nevada, Reno, United States.ORCID 0000-0002-2086-5453
Caoimhin S GriffinDepartment of Pharmacology, Center for Molecular and Cellular Signaling in the Cardiovascular System, University of Nevada, Reno, United States.
Evan YamasakiDepartment of Pharmacology, Center for Molecular and Cellular Signaling in the Cardiovascular System, University of Nevada, Reno, United States.
Michael G AlvaradoDepartment of Pharmacology, Center for Molecular and Cellular Signaling in the Cardiovascular System, University of Nevada, Reno, United States.ORCID 0000-0002-3489-9021
Martin T JohnsonDepartment of Cellular and Molecular Physiology, Penn State Cancer Institute, Penn State University, Reno, United States.
Mohamed TrebakDepartment of Cellular and Molecular Physiology, Penn State Cancer Institute, Penn State University, Reno, United States.ORCID 0000-0001-6759-864X
Scott EarleyDepartment of Pharmacology, Center for Molecular and Cellular Signaling in the Cardiovascular System, University of Nevada, Reno, United States.ORCID 0000-0001-9560-2941
University of Nevada, Reno · USPennsylvania State University · US
Funding
Transgenic Animal Genotyping and Phenotyping CoreP20GM130459 · NIGMS · UNIVERSITY OF NEVADA RENO · PI Nathan Grainger · 2019 to 2026
$20.3MTRP channels as fundamental sensors of the cerebral microcirculationR35HL155008 · NHLBI · UNIVERSITY OF ROCHESTER · PI Scott Earley · 2021 to 2026
$5.5MCa2+ Signaling Networks in Health and DiseaseR35HL150778 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TREBAK, MOHAMED · 2020 to 2025
$5.4MTRP Channel-Dependent Regulation of Arterial Tone (Renewal)R01HL091905 · NHLBI · UNIVERSITY OF NEVADA RENO · PI EARLEY, SCOTT · 2009 to 2020
$5.1MThe Neural Mechanisms of HypertensionR01HL122770 · NHLBI · UNIVERSITY OF ROCHESTER · PI FENG EARLEY, YUMEI · 2015 to 2023
$4.2MMechanisms of Functional Vascular Impairment In Genetic Models of Cerebral Small Vessel DiseaseRF1NS110044 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EARLEY, SCOTT, GOULD, DOUGLAS · 2018 to 2022
$3.3MRole of ANO1 Channels and Its Regulation by PIP2 in EC-Coupling in Pulmonary Artery MyocytesR01HL146054 · NHLBI · UNIVERSITY OF NEVADA RENO · PI EARLEY, SCOTT, LEBLANC, NORMAND · 2019 to 2022
$2.0MSensory mechanisms in brain capillary endothelial cells that initiate functional hyperemiaR01HL139585 · NHLBI · UNIVERSITY OF NEVADA RENO · PI EARLEY, SCOTT · 2018 to 2020
$1.7MStructural Basis of Peripheral Coupling Sites Regulating Arterial Smooth Muscle Contractility (A1)R01HL137852 · NHLBI · UNIVERSITY OF NEVADA RENO · PI EARLEY, SCOTT · 2018 to 2020
$1.6MDevelopment and validation of novel models for cerebral small vessel disease and vascular cognitive impairmentR61NS115132 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAUMEIL, MYRIAM MARIANNE, EARLEY, SCOTT · 2019 to 2020
$1.1MPericyte Control of Junctional Blood FlowK01HL138215 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI GONZALES, ALBERT LOUIS · 2017 to 2021
$744kNHLBI NIH HHS K01 HL138215NHLBI NIH HHS R01 HL091905NHLBI NIH HHS R01 HL122770NHLBI NIH HHS R01 HL137852NHLBI NIH HHS R01 HL139585NHLBI NIH HHS R01 HL146054NHLBI NIH HHS R35 HL150778NHLBI NIH HHS R35 HL155008NIGMS NIH HHS P20 GM130459NINDS NIH HHS R61 NS115132NINDS NIH HHS RF1 NS110044
Abstract
Peripheral coupling between the sarcoplasmic reticulum (SR) and plasma membrane (PM) forms signaling complexes that regulate the membrane potential and contractility of vascular smooth muscle cells (VSMCs). The mechanisms responsible for these membrane interactions are poorly understood. In many cells, STIM1 (stromal interaction molecule 1), a single-transmembrane-domain protein that resides in the endoplasmic reticulum (ER), transiently moves to ER-PM junctions in response to depletion of ER Ca
Indexed as
CalciumMuscle, Smooth, VascularAnimalsCalcium SignalingMembrane ProteinsMiceMyocytes, Smooth MuscleSarcoplasmic ReticulumStromal Interaction Molecule 1CalciumMembrane ProteinsStim1 protein, mouseStromal Interaction Molecule 1BK channelscerebral arterymembrane junctionsmolecular biophysicsmouseperipheral couplingSTIM1structural biologyTRPM4 channels
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