Evidence map›Paper›PMID 35147054›Full record

ArticleDrug delivery2022

Ion-pair compounds of diacerein for enhancing skin permeability

Yan Liang, Manzhen Duan, Wei Yi, Teng Zhang, Yonggang Wang, Zhiming Wu, Huaibo Tang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yan LiangDepartment of Pharmacy, School of Chemistry, Xiangtan University, Xiangtan, China.
Manzhen DuanDepartment of Pharmaceutical Engineering, School of Chemical Engineering, Xiangtan University, Xiangtan, China.
Wei YiDepartment of Pharmacy, School of Chemistry, Xiangtan University, Xiangtan, China.
Teng ZhangDepartment of Pharmacy, School of Chemistry, Xiangtan University, Xiangtan, China.
Yonggang WangDepartment of Pharmacy, School of Chemistry, Xiangtan University, Xiangtan, China.
Zhiming WuDepartment of Pharmaceutical Engineering, School of Chemical Engineering, Xiangtan University, Xiangtan, China.
Huaibo TangDepartment of Pharmacy, School of Chemistry, Xiangtan University, Xiangtan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This research aimed to investigate how the relationship between counter ion and diacerein (DCN) exerts an effect on the skin penetration of DCN ion-pair compounds. After the ion-pair compounds were formed by DCN and organic amines with different functional groups, the hydrogen bond of these compounds was confirmed by Fourier-transform infrared (FTIR) spectroscopy and molecular docking. The skin of porcine ears was employed to conduct the

Indexed as

Administration, CutaneousAnimalsAnthraquinonesBiogenic AminesMolecular Docking SimulationSkin AbsorptionSwineAnthraquinonesBiogenic AminesdiacereinDiacereinion-pairmolecular simulationtransdermal

Identifiers

PMID35147054
PMCPMC8843160

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.