Evidence map›Paper›PMID 35146961›Full record

ArticleBrain and behavior2022

Associations between alcohol use and peripheral, genetic, and epigenetic markers of oxytocin in a general sample of young and older adults.

Jillian M Rung, Quintin A Kidder, Marilyn Horta, H P Nazarloo, C Sue Carter, Meredith S Berry, Natalie C Ebner

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jillian M RungDepartment of Psychology, University of Florida, Gainesville, Florida, USA.ORCID 0000-0002-5945-6454
Quintin A KidderDepartment of Psychology, University of Florida, Gainesville, Florida, USA.
Marilyn HortaDepartment of Psychology, University of Florida, Gainesville, Florida, USA.
H P NazarlooKinsey Institute, Indiana University, Bloomington, Indiana, USA.
C Sue CarterKinsey Institute, Indiana University, Bloomington, Indiana, USA.
Meredith S BerryDepartment of Psychology, University of Florida, Gainesville, Florida, USA.
Natalie C EbnerDepartment of Psychology, University of Florida, Gainesville, Florida, USA.ORCID 0000-0002-2705-7520
University of Florida Health · USIndiana University Bloomington · USUniversity of Florida · US

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
UF Clinical and Translational Science AwardUL1TR000064 · NCATS · UNIVERSITY OF FLORIDA · PI NELSON, DAVID R · 2012 to 2014
$12.2M
UF Substance Abuse Training Center in Public HealthT32DA035167 · NIDA · UNIVERSITY OF FLORIDA · PI Linda B. Cottler · 2014 to 2026
$4.8M
Translational Science Training to Reduce the Impact of Alcohol on HIV InfectionT32AA025877 · NIAAA · UNIVERSITY OF FLORIDA · PI Robert L Cook, DEBRA E LYON · 2018 to 2026
$3.3M
Mechanisms of Oxytocin's Analgesia in Older Adults (Diversity Supplement)R01AG059809 · NIA · UNIVERSITY OF FLORIDA · PI CRUZ-ALMEIDA, YENISEL, EBNER, NATALIE C · 2018 to 2022
$1.8M
Opioid-Sparing and Pain-Reducing Properties of Syntocinon: A Dose-Effect DeterminationK01DA052673 · NIDA · UNIVERSITY OF FLORIDA · PI Meredith Berry · 2022 to 2026
$916k
Research Network on Decision Neuroscience and AgingR24AG039350 · NIA · STANFORD UNIVERSITY · PI CARSTENSEN, LAURA L · 2010 to 2014
$896k
NCATS NIH HHS UL1 TR000064NCATS NIH HHS UL1 TR001427NIAAA NIH HHS T32 AA025877NIA NIH HHS R01 AG059809NIA NIH HHS R24 AG039350NIDA NIH HHS K01 DA052673NIDA NIH HHS L30 DA052084NIDA NIH HHS T32 DA035167
6 · The paper itself

Abstract

introductionHuman and nonhuman animal research suggests that greater oxytocin (OT) activity is protective against harmful substance use. Most research on this topic is preclinical, with few studies evaluating the association between substance use and individual differences in the human OT system. The present study sought to fill this gap by evaluating the relationship between alcohol use and multiple biological measures of OT activity in an overall low to moderate-drinking sample.

methodAs part of a larger study, generally healthy young (n = 51) and older (n = 53) adults self-reported whether they regularly used alcohol and how much alcohol they consumed per week. Participants also provided blood samples from which peripheral OT, and in an age-heterogeneous subset of participants (n = 56) variation in the oxytocin receptor gene (the OXTR rs53576 polymorphism) and OXTR DNA methylation levels (at cytosine-guanine dinucleotide sites -860, -924, -934), were obtained.

resultsA-allele carriers of the OXTR rs53579 polymorphism were less likely to regularly consume alcohol. Among regular alcohol consumers, number of alcoholic drinks per week was positively associated with peripheral OT in regression models excluding observations of high influence (postdiagnostic models). Number of alcoholic drinks per week was consistently negatively associated with OXTR DNA methylation at site -860; and with OXTR DNA methylation at site -924 in postdiagnostic models.

conclusionsThe significant associations between alcohol use and individual differences in OT activity support the involvement of the OT system in alcohol use, which most likely reflect the role of OT when alcohol use is under control of its rewarding properties and/or the acute impacts of alcohol on the OT system. Additional research with markers of OT activity and alcohol use, particularly longitudinal, is needed to clarify the bidirectional effects of OT and alcohol use in moderate to harmful drinking and dependence.

Indexed as

Alcohol DrinkingOxytocinReceptors, OxytocinAdultDNA MethylationEpigenesis, GeneticHumansPolymorphism, Single NucleotideOXTR protein, humanOxytocinReceptors, OxytocinalcoholDNA methylationgenetic predispositiongenotypeoxytocinperipheralpolymorphismsubstance use

Identifiers

PMID35146961
PMCPMC8933764
OpenAlexW4211246638

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.