Evidence map›Paper›PMID 35146949›Full record

ArticleESC heart failure2022

The value of echocardiographic measurement of epicardial adipose tissue in heart failure patients.

Gijs van Woerden, Dirk J van Veldhuisen, Thomas M Gorter, Bob Ophuis, Huitzilihuitl Saucedo-Orozco, Vanessa P M van Empel, Tineke P Willems, Bastiaan Geelhoed, Michiel Rienstra, Berend Daan Westenbrink

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In one paragraph

Article in ESC heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Prognostic value of epicardial and pericardial adipose tissue in patients with chronic heart failure.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gijs van WoerdenDepartment of Cardiology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Dirk J van VeldhuisenDepartment of Cardiology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Thomas M GorterDepartment of Cardiology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Bob OphuisDepartment of Cardiology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Huitzilihuitl Saucedo-OrozcoDepartment of Cardiology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Vanessa P M van EmpelDepartment of Cardiology, University of Maastricht, Medical University Centre Maastricht, Maastricht, The Netherlands.
Tineke P WillemsDepartment of Radiology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Bastiaan GeelhoedDepartment of Cardiology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Michiel RienstraDepartment of Cardiology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Berend Daan WestenbrinkDepartment of Cardiology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsEpicardial adipose tissue (EAT) is increasingly recognized as an important factor in the pathophysiology of heart failure (HF). Cardiac magnetic resonance (CMR) imaging is the gold-standard imaging modality to evaluate EAT size, but in contrast to echocardiography, CMR is costly and not widely available. We investigated EAT thickness on echocardiography in relation to EAT volume on CMR, and we assessed the agreement between observers for measuring echocardiographic EAT. METHODS AND

resultsPatients with HF and left ventricular ejection fraction >40% were enrolled. All patients underwent CMR imaging and transthoracic-echocardiography. EAT volume was quantified on CMR short-axis cine-stacks. Echocardiographic EAT thickness was measured on parasternal long-axis and short-axis views. Linear regression analyses were used to assess the association between EAT volume on CMR and EAT thickness on echocardiography. Intraclass correlation coefficient (ICC) was used to assess the interobserver agreement as well as the intraobserver agreement. EAT on CMR and echocardiography was evaluated in 117 patients (mean age 71 ± 10 years, 49% women and mean left ventricular ejection fraction 54 ± 7%). Mean EAT volume on CMR was 202 ± 64 mL and ranged from 80 to 373 mL. Mean EAT thickness on echocardiography was 3.8 ± 1.5 mm and ranged from 1.7 to 10.2 mm. EAT volume on CMR and EAT thickness on echocardiography were significantly correlated (junior-observer: r = 0.62, P < 0.001, senior-observer: r = 0.33, P < 0.001), and up to one-third of the variance in EAT volume was explained by EAT thickness (R

conclusionsThere was a modest correlation between EAT volume on CMR and EAT thickness on echocardiography. Limited agreement between junior and senior observers for measuring echocardiographic EAT was observed. EAT thickness on echocardiography is limited in estimating EAT volume.

Indexed as

Heart FailureVentricular Function, LeftAdipose TissueAgedAged, 80 and overEchocardiographyFemaleHumansMaleMiddle AgedStroke VolumeCardiac magnetic resonance imagingEchocardiographyEpicardial adipose tissueHFmrEFHFpEF

Identifiers

PMID35146949
PMCPMC8934911

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.