Evidence map›Paper›PMID 35146857›Full record

ArticleAngewandte Chemie (International ed. in English)2022

Active Mechanical Threading by a Molecular Motor.

Nicolai N Bach, Verena Josef, Harald Maid, Henry Dube

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. A Molecular Machine Directs the Synthesis of a Rotaxane.Angewandte Chemie (International ed. in English) · 2026
    Article
  3. Article
  4. Coupling Rotary Motion to Helicene Inversion within a Molecular Motor.Angewandte Chemie (International ed. in English) · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Coupled Rotary Motion in Molecular Motors.Journal of the American Chemical Society · 2024
    Article
  9. Controlling Swing Rates in Macrocyclic Molecular Mortise Hinges.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. The Influence of Strain on the Rotation of an Artificial Molecular Motor.Angewandte Chemie (International ed. in English) · 2022
    Article
  18. Photopharmacology of Antimitotic Agents.International journal of molecular sciences · 2022
    Review
  19. Active Mechanical Threading by a Molecular Motor.Angewandte Chemie (International ed. in English) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nicolai N BachFriedrich-Alexander-Universität Erlangen-Nürnberg, Department of Chemistry and Pharmacy, Nikolaus-Fiebiger-Str. 10, 91058, Erlangen, Germany.
Verena JosefFriedrich-Alexander-Universität Erlangen-Nürnberg, Department of Chemistry and Pharmacy, Nikolaus-Fiebiger-Str. 10, 91058, Erlangen, Germany.
Harald MaidFriedrich-Alexander-Universität Erlangen-Nürnberg, Department of Chemistry and Pharmacy, Nikolaus-Fiebiger-Str. 10, 91058, Erlangen, Germany.
Henry DubeFriedrich-Alexander-Universität Erlangen-Nürnberg, Department of Chemistry and Pharmacy, Nikolaus-Fiebiger-Str. 10, 91058, Erlangen, Germany.ORCID 0000-0002-5055-9924

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Molecular motors transform external energy input into directional motions and offer exquisite precision for nano-scale manipulations. To make full use of molecular motor capacities, their directional motions need to be transmitted and used for powering downstream molecular events. Here we present a macrocyclic molecular motor structure able to perform repetitive molecular threading of a flexible tetraethylene glycol chain through the macrocycle. This mechanical threading event is actively powered by the motor and leads to a direct translation of the unidirectional motor rotation into unidirectional translation motion (chain versus ring). The mechanism of the active mechanical threading is elucidated and the actual threading step is identified as a combined helix inversion and threading event. The established molecular machine function resembles the crucial step of macroscopic weaving or sewing processes and therefore offers a first entry point to a "molecular knitting" counterpart.

Indexed as

ThermodynamicsRotationHemithioindigoIndigoidsMolecular MachinesMolecular MotorsPhotochemistry

Identifiers

PMID35146857
PMCPMC9314141

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.