ArticleThe EMBO journal2022
Plant immunity suppression via PHR1-RALF-FERONIA shapes the root microbiome to alleviate phosphate starvation.
Article in The EMBO journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed, 143 citations in OpenAlex.
- Pathogen-Induced Cell Wall Remodeling and Immune Signaling in Plants.The plant pathology journal · 2026Review
- SlMED25-SlPHR3-SlSPX2 module fine-tunes SlPHR3-mediated transcriptional activation of phosphate starvation response in tomato.Journal of integrative plant biology · 2026Article
- Plasma membrane HThe New phytologist · 2026Article
- Comparative Secretome Profiling ofPlants (Basel, Switzerland) · 2026Article
- Peptide hormones in shaping root system architecture and environmental adaptation: Current advances and translational perspectives.Plant communications · 2026Review
- The Mitogen-Activated Protein Kinase GhNTF3 Modulates the Arbuscular Mycorrhizal Symbiosis-Immunity Trade-Off in Cotton by Regulating Salicylic Acid Biosynthesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Plant Peptide Hormones: Distinctive Horizons in Plant Development and Stress Resilience.Plant, cell & environment · 2026Review
- Endogenous RALF peptide function is required for powdery mildew host colonization.The New phytologist · 2026Article
- ZmPHR1 and ZmPHR2 Mediate Metabolic and Microbial Regulation of Maize Adaptation to Phosphorus Heterogeneity.Plant, cell & environment · 2026Article
- Integrated signaling mechanisms governing root hair growth via transcriptional master regulators.The Plant journal : for cell and molecular biology · 2026Review
- The plant microbiota: From theoretical advances to applications.Fundamental research · 2026Review
- Peptide signaling at the intersection of growth, nutrient sensing, and stress responses.The Plant journal : for cell and molecular biology · 2026Review
- Silencing of the Mycorrhiza-Inducible Phosphate TransporterPlants (Basel, Switzerland) · 2026Article
- Deciphering the role of NtabCrRLK47 in rhizosphere microbiome remodeling and tobacco growth promotion.Frontiers in plant science · 2026Article
- Gene family ofFrontiers in plant science · 2026Article
- Identification of microbiome-associated loci in super hybrid rice reveals the regulation of OsBRI1 on nitrogen-dependent root microbiome assembly.BMC plant biology · 2025Article
- The role of sucrose in phosphate starvation response: transcriptomic and physiological insights in Arabidopsis Thaliana.BMC plant biology · 2025Article
- The interplay of RALF structural and signaling functions in plant-microbe interactions.PLoS pathogens · 2025Review
- Microbial drivers of root plasticity.The New phytologist · 2025Review
- Identification of PpTHE1, a cell wall integrity sensor regulating the increased duration of harvest window in slow-melting flesh peach, through the assembly of a chromosome-level reference genome of Prunus persica.Plant biotechnology journal · 2025Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The microbiome plays an important role in shaping plant growth and immunity, but few plant genes and pathways impacting plant microbiome composition have been reported. In Arabidopsis thaliana, the phosphate starvation response (PSR) was recently found to modulate the root microbiome upon phosphate (Pi) starvation through the transcriptional regulator PHR1. Here, we report that A. thaliana PHR1 directly binds to the promoters of rapid alkalinization factor (RALF) genes, and activates their expression under phosphate-starvation conditions. RALFs in turn suppress complex formation of pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) receptor through FERONIA, a previously-identified PTI modulator that increases resistance to certain detrimental microorganisms. Suppression of immunity via the PHR1-RALF-FERONIA axis allows colonization by specialized root microbiota that help to alleviate phosphate starvation by upregulating the expression of PSR genes. These findings provide a new paradigm for coordination of host-microbe homeostasis through modulating plant innate immunity after environmental perturbations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.