Antenatal Steroids and Cord Blood T-cell Glucocorticoid Receptor DNA Methylation and Exon 1 Splicing.
Jeanette R Carpenter, Kathleen A Jablonski, Jordan Koncinsky, Michael W Varner, Cynthia Gyamfi-Bannerman, Lisa A Joss-Moore, Eunice Kennedy Shriver National Institute of Child Health, Human Development Maternal-Fetal Medicine Units Network
Article in Reproductive sciences (Thousand Oaks, Calif.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
7 authors at 3 institutions in 1 country.
Jeanette R CarpenterObstetrics & Gynecology, University of Utah, Salt Lake City, UT, USA.
Kathleen A JablonskiMilken School of Public Health, Biostatistics Center, George Washington University, Washington, D.C, USA.
Jordan KoncinskyDepartment of Pediatrics, University of Utah, 295 Chipeta Way, Salt Lake City, UT, 84108, USA.
Michael W VarnerObstetrics & Gynecology, University of Utah, Salt Lake City, UT, USA.
Cynthia Gyamfi-BannermanObstetrics & Gynecology, Columbia University, New York, NY, USA.
Lisa A Joss-MooreDepartment of Pediatrics, University of Utah, 295 Chipeta Way, Salt Lake City, UT, 84108, USA. lisa.joss-moore@hsc.utah.edu.
Eunice Kennedy Shriver National Institute of Child Health, Human Development Maternal-Fetal Medicine Units Network
University of Utah · USColumbia University · USMilken Institute · US
Funding
Data Coord Ctr-NICHD Cooperative Multicenter Maternal Medicine Units Research NetU10HD036801 · NICHD · GEORGE WASHINGTON UNIVERSITY · PI CLIFTON, REBECCA GERSNOVIEZ · 2009 to 2021
$174.2M
UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI KATHARINE S ULLMAN · 1986 to 2026
$72.6M
SARS-CoV-2 Vaccine Pregnancy RegistryU24HD036801 · NICHD · GEORGE WASHINGTON UNIVERSITY · PI Rebecca Gersnoviez Clifton · 2021 to 2026
$39.2M
MATERNAL FETAL RESEARCH NETWORK: DATA COORDINATING CTRU01HD036801 · NICHD · GEORGE WASHINGTON UNIVERSITY · PI THOM, ELIZABETH ANN · 1998 to 2008
$27.0M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
NICHD Maternal Fetal Medicine Units NetworkU10HD034208 · NICHD · UNIVERSITY OF UTAH · PI VARNER, MICHAEL W. · 1996 to 2015
$16.6M
NICHD Maternal Fetal Medicine Units NetworkU10HD040485 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WAPNER, RONALD · 2001 to 2015
$12.5M
Pulmonary Complications in a Birth Cohort after a Randomized Trial of Antenatal Corticosteroids: the ALPS Follow-Up Study - Data Coordinating Center (ALPS FS - DCC)R01HL098354 · NHLBI · GEORGE WASHINGTON UNIVERSITY · PI CLIFTON, REBECCA GERSNOVIEZ, THOM, ELIZABETH ANN · 2016 to 2021
$9.4M
Randomized Trial of Antenatal Late Preterm Steroids (ALPS) - DCCU01HL098354 · NHLBI · GEORGE WASHINGTON UNIVERSITY · PI THOM, ELIZABETH ANN · 2010 to 2012
$4.6M
Maternal-Fetal Medicine Units (MFMU) NetworkUG1HD040485 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Noelia Milena Modad Zork · 2016 to 2026
$3.6M
UofU Maternal-Fetal Medicine Units (MFMU) Network: Clinical CentersUG1HD034208 · NICHD · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Torri D Metz · 2016 to 2026
$3.4M
NICHD Maternal Fetal Medicine Units NetworkUG1HD027915 · NICHD · OHIO STATE UNIVERSITY · PI Maged Costantine · 2016 to 2026
Antenatal administration of glucocorticoids such as betamethasone (BMZ) during the late preterm period improves neonatal respiratory outcomes. However, glucocorticoids may elicit programming effects on immune function and gene regulation. Here, we test the hypothesis that exposure to antenatal BMZ alters cord blood immune cell composition in association with altered DNA methylation and alternatively expressed Exon 1 transcripts of the glucocorticoid receptor (GR) gene in cord blood CD4
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Antenatal Steroids and Cord Blood T-cell Glucocorticoid Receptor DNA Methylation and Exon 1 Splicing. · full record | OpenQuestion