ArticleDaru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences2022
Influence of methylxanthines isolated from Bancha green tea on the pharmacokinetics of sildenafil in rats.
Article in Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 4 citations in OpenAlex.
- Green Tea: Current Knowledge and Issues.Foods (Basel, Switzerland) · 2025Review
- Effects of polyphenols extracted from Keemun black tea on CYP450s activity and molecular mechanisms.Food science & nutrition · 2024Article
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5 authors at 1 institution in 1 country.
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Abstract
backgroundSildenafil is used to treat erectile dysfunction and pulmonary arterial hypertension and is metabolized in the liver mainly by CYP3A4, thus co-administration with drugs or herbal extracts that affect CYP3A4 activity may lead to drug-drug or drug-herb interactions, respectively. The aim of the present study was to evaluate the influence of single and multiple oral doses of methylxanthine fraction, isolated from Bancha green tea leaves on the pharmacokinetics of sildenafil in rats.
methodsRats were given sildenafil alone as well as simultaneously with methylxanthines or ketoconazole. The plasma concentrations of sildenafil were measured with high-performance liquid chromatography method with ultraviolet detection. The pharmacokinetic parameters of sildenafil were calculated by non-compartmental analysis.
resultsConcomitant use of sildenafil with a single oral dose of methylxanthines resulted in a decrease in C
conclusionDrug-herb interactions were observed when sildenafil was co-administered with Bancha methylxanthines in rats. Further in vivo studies about the potential drug interactions between sildenafil and methylxanthines, especially caffeine, are needed to clarify mechanisms underlying the observed changes in sildenafil pharmacokinetics.
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