Evidence map›Paper›PMID 35146636›Full record

ArticleEuropean journal of drug metabolism and pharmacokinetics2022

Inhibition of Cytochrome P450s by Strobilanthes crispus Sub-Fraction (F3): Implication for Herb-Drug Interaction.

Ya Fen Yong, Mervyn Wing On Liew, Nik Soriani Yaacob

Abstract read
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In one paragraph

Article in European journal of drug metabolism and pharmacokinetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Ya Fen YongDepartment of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kota Bharu, Kelantan, Malaysia.ORCID http://orcid.org/0000-0002-8979-1771
Mervyn Wing On LiewInstitute for Research in Molecular Medicine, Universiti Sains Malaysia, Main Campus, 11800, Minden, Pulau Pinang, Malaysia. mervynliew@usm.my.ORCID http://orcid.org/0000-0002-3398-8786
Nik Soriani YaacobDepartment of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kota Bharu, Kelantan, Malaysia. niksoriani@usm.my.ORCID http://orcid.org/0000-0002-9679-6917
Hospital Universiti Sains Malaysia · MYUniversiti Sains Malaysia · MY

Funding

Kementerian Sains, Teknologi dan Inovasi 02-01-05-SF0732Universiti Sains Malaysia 1001.PPSP.8012295
6 · The paper itself

Abstract

BACKGROUND AND

objectiveStrobilanthes crispus Blume sub-fraction (F3) has been reported to be cytotoxic against cancer cells and to cause murine mammary tumor regression. Potential utilization of F3 as an adjuvant in breast cancer treatment to alleviate chemotherapeutic drug resistance is currently hampered by potential cytochrome P450 (CYP)-mediated herb-drug interactions (HDIs). The current study assessed the inhibitory potency of F3 towards five CYP enzymes involved in tamoxifen metabolism.

methodsPotential CYP inhibition by F3 was first determined using fluorescence assays, using known CYP inhibitors as reference. To further ascertain the inhibitory potency and mode of inhibition, high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) analysis of specific metabolites of a CYP probe substrate was conducted.

resultsThe half-maximal inhibitory concentration (IC

conclusionTaken together, the results revealed a low probability of inhibition by F3 on CYP enzymes involved in tamoxifen metabolism. However, further in vivo investigation is necessary for potential F3 interaction with CYP2C9. The utility of a preliminary in vitro approach in the assessment of potential HDI was demonstrated in this study.

Indexed as

Herb-Drug InteractionsMicrosomes, LiverAnimalsCytochrome P-450 CYP2C9Cytochrome P-450 Enzyme SystemMiceTamoxifenTandem Mass SpectrometryCytochrome P-450 CYP2C9Cytochrome P-450 Enzyme SystemTamoxifen

Identifiers

PMID35146636
OpenAlexW4211186701

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.