Evidence map›Paper›PMID 35146590›Full record

ArticlePharmaceutical research2022

A Semi-Physiological Three-Compartment Model Describes Brain Uptake Clearance and Efflux of Sucrose and Mannitol after IV Injection in Awake Mice.

Behnam Noorani, Ekram Ahmed Chowdhury, Faleh Alqahtani, Md Sanaullah Sajib, Yeseul Ahn, Ehsan Nozohouri, Dhavalkumar Patel, Constantinos Mikelis, Reza Mehvar, Ulrich Bickel

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutical research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Towards Precise Modelling of Diffusion Across the Blood-Brain Barrier.Advances in experimental medicine and biology · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

Behnam Noorani *Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, 1300 S Coulter St., Amarillo, Texas, 79106, USA.
Ekram Ahmed Chowdhury *Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, 1300 S Coulter St., Amarillo, Texas, 79106, USA.
Faleh Alqahtani *Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, 1300 S Coulter St., Amarillo, Texas, 79106, USA.
Md Sanaullah SajibDepartment of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, 1300 S Coulter St., Amarillo, Texas, 79106, USA.
Yeseul AhnDepartment of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, 1300 S Coulter St., Amarillo, Texas, 79106, USA.
Ehsan NozohouriDepartment of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, 1300 S Coulter St., Amarillo, Texas, 79106, USA.
Dhavalkumar PatelLC-MS Core Facility, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, 79106, USA.
Constantinos MikelisDepartment of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, 1300 S Coulter St., Amarillo, Texas, 79106, USA.
Reza MehvarCenter for Blood-Brain Barrier Research, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, 79106, USA. mehvar@chapman.edu.
Ulrich BickelDepartment of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, 1300 S Coulter St., Amarillo, Texas, 79106, USA. Ulrich.Bickel@ttuhsc.edu.
Texas Tech University Health Sciences Center · USTexas Tech University · US

Funding

Novel Class of Chemotherapeutic Agents for Treatment of Metastatic Triple-negative Breast CancerR15CA231339 · NCI · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI GERMAN, NADEZHDA A, MIKELIS, CONSTANTINOS MARIOS · 2018 to 2018
$459k
NCI NIH HHS R15 CA231339
6 · The paper itself

Abstract

purposeTo evaluate a three-compartmental semi-physiological model for analysis of uptake clearance and efflux from brain tissue of the hydrophilic markers sucrose and mannitol, compared to non-compartmental techniques presuming unidirectional uptake.

methodsStable isotope-labeled [

resultsThe three-compartment model was able to describe the experimental data well, yielding estimates for K

conclusionsUsing the three-compartment model allows determination of K

Indexed as

Models, BiologicalAnimalsBrainChromatography, LiquidDrug Elimination RoutesInjections, IntravenousMaleMannitolMiceMice, Inbred C57BLPermeabilitySucroseTandem Mass SpectrometryTissue DistributionWakefulnessMannitolSucroseblood-brain barrierbulk flowLC-MS/MSpharmacokinetics

Identifiers

PMID35146590
PMCPMC9645436
OpenAlexW4211143993

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.