Evidence map›Paper›PMID 35146571›Full record

ArticleEuropean archives of psychiatry and clinical neuroscience2022

Investigating the phenotypic and genetic associations between personality traits and suicidal behavior across major mental health diagnoses.

Janos L Kalman, Tomoya Yoshida, Till F M Andlauer, Eva C Schulte, Kristina Adorjan, Martin Alda, Raffaela Ardau, Jean-Michel Aubry, Katharina Brosch, Monika Budde and 51 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European archives of psychiatry and clinical neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Completed suicide is associated with a higher polygenic burden for psychiatric disorders.European archives of psychiatry and clinical neuroscience · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

61 authors at 20 institutions in 11 countries.

Janos L KalmanInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Nussbaumstr. 7, 80336, Munich, Germany. janos.kalman@med.uni-muenchen.de.ORCID http://orcid.org/0000-0003-0930-4214
Tomoya YoshidaNational Center for Global Health and Medicine, Tokyo, Japan.
Till F M AndlauerDepartment of Neurology, Klinikum Rechts Der Isar, School of Medicine, Technical University of Munich, Munich, Germany.
Eva C SchulteInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Nussbaumstr. 7, 80336, Munich, Germany.
Kristina AdorjanInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Nussbaumstr. 7, 80336, Munich, Germany.
Martin AldaDepartment of Psychiatry, Dalhousie University, Halifax, Canada.
Raffaela ArdauUnit of Clinical Pharmacology, University Hospital Agency of Cagliari, Cagliari, Italy.
Jean-Michel AubryDepartment of Psychiatry, Geneva University Hospitals, Geneva, Switzerland.
Katharina BroschDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Monika BuddeInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Nussbaumstr. 7, 80336, Munich, Germany.
Caterina ChillottiUnit of Clinical Pharmacology, University Hospital Agency of Cagliari, Cagliari, Italy.
Piotr M CzerskiDepartment of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland.
Raymond J DePauloDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Andreas ForstnerCentre for Human Genetics, University of Marburg, Marburg, Germany.
Fernando S GoesDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Maria Grigoroiu-SerbanescuPsychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania.
Paul GrofMood Disorders Clinic of Ottawa, Ottawa, ON, Canada.
Dominik GrotegerdInstitute for Translational Psychiatry, University of Munster, Munster, Germany.
Tim HahnInstitute for Translational Psychiatry, University of Munster, Munster, Germany.
Maria HeilbronnerInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Nussbaumstr. 7, 80336, Munich, Germany.
Roland HaslerDepartment of Psychiatry, Geneva University Hospitals, Geneva, Switzerland.
Urs HeilbronnerInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Nussbaumstr. 7, 80336, Munich, Germany.
Stefanie Heilmann-HeimbachInstitute of Human Genetics, School of Medicine &, University of Bonn, University Hospital Bonn, Bonn, Germany.
Pawel KapelskiDepartment of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland.
Tadafumi KatoDepartment of Psychiatry and Behavioral Science, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Mojtaba Oraki KohshourInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Nussbaumstr. 7, 80336, Munich, Germany.
Susanne MeinertInstitute for Translational Psychiatry, University of Munster, Munster, Germany.
Tina MellerDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Igor NenadićDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Markus M NöthenInstitute of Human Genetics, School of Medicine &, University of Bonn, University Hospital Bonn, Bonn, Germany.
Tomas NovakNational Institute of Mental Health, Klecany, Czech Republic.
Nils OpelInstitute for Translational Psychiatry, University of Munster, Munster, Germany.
Joanna PawlakDepartment of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland.
Julia-Katharina PfarrDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
James B PotashDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Daniela Reich-ErkelenzInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Nussbaumstr. 7, 80336, Munich, Germany.
Jonathan ReppleInstitute for Translational Psychiatry, University of Munster, Munster, Germany.
Hélène Richard-LepourielDepartment of Psychiatry, Geneva University Hospitals, Geneva, Switzerland.
Marcella RietschelDepartment of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
Kai G RingwaldDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Guy RouleauMontreal Neurological Institute, McGill University, Montreal, Canada.
Sabrina SchauppInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Nussbaumstr. 7, 80336, Munich, Germany.
Fanny SennerInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Nussbaumstr. 7, 80336, Munich, Germany.
Giovanni SeverinoDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Alessio SquassinaDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Frederike SteinDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Pavla StopkovaNational Institute of Mental Health, Klecany, Czech Republic.
Fabian StreitDepartment of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
Katharina ThielInstitute for Translational Psychiatry, University of Munster, Munster, Germany.
Florian Thomas-OdenthalDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Gustavo TureckiThe Douglas Research Centre, McGill University, Montreal, Canada.
Joanna Twarowska-HauserDepartment of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland.
Alexandra WinterInstitute for Translational Psychiatry, University of Munster, Munster, Germany.
Peter P ZandiDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
John R KelsoeDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Consortium on Lithium Genetics (ConLiGen), PsyCourse
Peter FalkaiDepartment of Psychiatry and Psychotherapy, University Hospital Munich, Munich, Germany.
Udo DannlowskiInstitute for Translational Psychiatry, University of Munster, Munster, Germany.
Tilo KircherDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Thomas G Schulze *Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Nussbaumstr. 7, 80336, Munich, Germany.
Sergi Papiol *Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Nussbaumstr. 7, 80336, Munich, Germany.
Johns Hopkins University · USPhilipps University of Marburg · DELMU Klinikum · DELudwig-Maximilians-Universität München · DEUniversity of Münster · DEPoznan University of Medical Sciences · PLUniversity of Bonn · DECharles University · CZSpitalul Clinic de Psihiatrie Alexandru Obregia · ROUniversity of Cagliari · ITUniversity of California San Diego · USDalhousie University · CAForschungszentrum Jülich · DEHeidelberg University · DEAhvaz Jundishapur University of Medical Sciences · IRMcGill University · CAMontreal Neurological Institute and Hospital · CAUniversity of Geneva · CHUniversity of Toronto · CAJuntendo University · JP

Funding

See Supplementary Material for a detailed list of funding sources See Supplementary Material for a detailed list of funding sources
6 · The paper itself

Abstract

Personality traits influence risk for suicidal behavior. We examined phenotype- and genotype-level associations between the Big Five personality traits and suicidal ideation and attempt in major depressive, bipolar and schizoaffective disorder, and schizophrenia patients (N = 3012) using fixed- and random-effects inverse variance-weighted meta-analyses. Suicidal ideations were more likely to be reported by patients with higher neuroticism and lower extraversion phenotypic scores, but showed no significant association with polygenic load for these personality traits. Our findings provide new insights into the association between personality and suicidal behavior across mental illnesses and suggest that the genetic component of personality traits is unlikely to have strong causal effects on suicidal behavior.

Indexed as

Major Depressive DisorderSuicidal IdeationHumansMental HealthPersonalityPhenotypeBipolar disorderMajor depressionPersonalityPolygenic scoreSchizophreniaSuicidal behavior

Identifiers

PMID35146571
PMCPMC9653330
OpenAlexW4211077356

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.