ArticleJournal of clinical immunology1986
IgA-associated renal diseases: antibodies to environmental antigens in sera and deposition of immunoglobulins and antigens in glomeruli.
Article in Journal of clinical immunology, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 134 citations in OpenAlex.
- IgA nephropathy: a novel pathway in immunopathogenesis dependent on the timing of Epstein-Barr virus infection.Frontiers in immunology · 2026Review
- Aberrant signaling in tonsillar B cells producing pathogenicFrontiers in immunology · 2026Review
- IgA Nephropathy: Pleiotropic impact of Epstein-Barr virus infection on immunopathogenesis and racial incidence of the disease.Frontiers in immunology · 2023Review
- The Role of Immune Modulation in Pathogenesis of IgA Nephropathy.Frontiers in medicine · 2020Review
- Application of Sparse Linear Discriminant Analysis and Elastic Net for Diagnosis of IgA Nephropathy: Statistical and Biological ViewpointsIranian biomedical journal · 2018Article
- Serum galactose-deficient-IgA1 and IgG autoantibodies correlate in patients with IgA nephropathy.PloS one · 2018Article
- What Genetics Tells Us About the Pathogenesis of IgA Nephropathy: The Role of Immune Factors and Infection.Kidney international reports · 2017Review
- The Origin and Activities of IgA1-Containing Immune Complexes in IgA Nephropathy.Frontiers in immunology · 2016Review
- Current Understanding of the Role of Complement in IgA Nephropathy.Journal of the American Society of Nephrology : JASN · 2015Review
- Can tonsillectomy modify the innate and adaptive immunity pathways involved in IgA nephropathy?Journal of nephrology · 2015Article
- Development of Animal Models of Human IgA Nephropathy.Drug discovery today. Disease models · 2014Article
- A panel of serum biomarkers differentiates IgA nephropathy from other renal diseases.PloS one · 2014Article
- IgA nephropathy and oxidative stress: news on clinically evaluated biomarkers hits the stage.International urology and nephrology · 2012Review
- Comparative Evaluation of HIV-1 Neutralization in External Secretions and Sera of HIV-1-Infected Women.The open AIDS journal · 2012Article
- Genetics and immunopathogenesis of IgA nephropathy.Clinical reviews in allergy & immunology · 2011Review
- Prophylactic and therapeutic efficacy of avian antibodies against influenza virus H5N1 and H1N1 in mice.PloS one · 2010Article
- Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity.The Journal of clinical investigation · 2009Article
- Role of aberrant glycosylation of IgA1 molecules in the pathogenesis of IgA nephropathy.Kidney & blood pressure research · 2008Review
- Development of immunoglobulin A nephropathy- like disease in beta-1,4-galactosyltransferase-I-deficient mice.The American journal of pathology · 2007Article
- IgA nephropathy in two adolescent sisters heterozygous for Fabry disease.Pediatric nephrology (Berlin, Germany) · 2006Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Levels of IgA1, IgA2, IgM, and IgG antibodies specific for 10 ubiquitous food and bacterial antigens were examined by radioimmunoassay in the sera of 29 patients with IgA-associated renal diseases and 22 normal individuals. No significant differences were observed between patient and normal groups in the levels of IgA1 antibodies, and IgA2 antibodies were detected in only a few individuals in either group. Minor differences in IgM or IgG antibodies were seen against some antigens. Significant positive correlations between IgA1 and IgG and between IgA1 and IgM antibodies to casein were found in the patient group. Analysis of the molecular form of serum IgA1 antibodies revealed that although the pattern of polymeric and monomeric forms varied between individuals and between antibody specificities, there was no preponderance of one form in either patient or normal groups. Examination of kidney biopsies from 50 patients with IgA-associated renal diseases revealed that IgA1 represented the predominant subclass deposited in the glomerular mesangium; glomeruli from three patients contained both IgA1 and IgA2. Seventy-eight percent of the patients also had deposits of IgM, although IgA and IgM deposits did not always coincide. When IgG was present in glomeruli (45% of patients), the IgG1 subclass predominated. J chain was detectable in glomeruli of only four patients. C3 was detected in glomeruli of 95% of the patients, although the distribution of C3 did not always coincide with that of IgA. Indirect immunofluorescence staining with rabbit antisera to various environmental antigens showed that milk protein antigens could be deposited in association with IgA in the glomerular mesangium.
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Registered trials
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