Evidence map›Paper›PMID 35146391›Full record

ArticleiScience2022

Fabrication of a new all-in-one microfluidic dielectrophoresis integrated chip and living cell separation.

Kyoichi Oshiro, Yoshikazu Wakizaka, Masayo Takano, Takayuki Itoi, Hiroki Ohge, Kazumi Koba, Kyoko Yarimizu, So Fujiyoshi, Fumito Maruyama

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 20 citations in OpenAlex.

  1. Precision Oncology Framework Using Circulating Tumor Cells.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Kyoichi OshiroDepartment of Infectious Diseases, Hiroshima University Hospital, Hiroshima 734-8551, Japan.
Yoshikazu WakizakaAFI Corporation, Medical Innovation Center, Building, 2nd Floor of Kyoto University, 53 Shogoin Kawahara-cho, Kyoto City, Sakyo-ku 606-8507, Japan.
Masayo TakanoAFI Corporation, Medical Innovation Center, Building, 2nd Floor of Kyoto University, 53 Shogoin Kawahara-cho, Kyoto City, Sakyo-ku 606-8507, Japan.
Takayuki ItoiAFI Corporation, Medical Innovation Center, Building, 2nd Floor of Kyoto University, 53 Shogoin Kawahara-cho, Kyoto City, Sakyo-ku 606-8507, Japan.
Hiroki OhgeDepartment of Infectious Diseases, Hiroshima University Hospital, Hiroshima 734-8551, Japan.
Kazumi KobaMicrobial Genomics and Ecology, Office of Industry-Academia-Government and Community Collaboration, Hiroshima University, 1-3-2 Kagamiyama, Higashi-Hiroshima City, Hiroshima 739-8511, Japan.
Kyoko YarimizuMicrobial Genomics and Ecology, Office of Industry-Academia-Government and Community Collaboration, Hiroshima University, 1-3-2 Kagamiyama, Higashi-Hiroshima City, Hiroshima 739-8511, Japan.
So FujiyoshiMicrobial Genomics and Ecology, Office of Industry-Academia-Government and Community Collaboration, Hiroshima University, 1-3-2 Kagamiyama, Higashi-Hiroshima City, Hiroshima 739-8511, Japan.
Fumito MaruyamaMicrobial Genomics and Ecology, Office of Industry-Academia-Government and Community Collaboration, Hiroshima University, 1-3-2 Kagamiyama, Higashi-Hiroshima City, Hiroshima 739-8511, Japan.
Hiroshima University · JPKyoto University · JPHiroshima University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microfluidic dielectrophoresis (DEP) technology has been applied to many devices to perform label-free target cell separation. Cells separated by these devices are used in laboratories, mainly for medical research. The present study designed a microfluidic DEP device to fabricate a rapid and semiautomated cell separation system in conjunction with microscopy to enumerate the separated cells. With this device, we efficiently segregated bacterial cells from liquid products and enriched one cell type from two mixed eukaryotic cell types. The device eliminated sample pretreatment and established cell separation by all-in-one operation in a lab-on-chip, requiring only a small sample volume (0.5-1 mL) to enumerate the target cells and completing the entire separation process within 30 min. Such a rapid cell separation technique is in high demand by many researchers to promptly characterize the target cells.

Indexed as

Biological sciencesBiological sciences research methodologiesBiology experimental methodsBiotechnologyMicrobiological method

Identifiers

PMID35146391
PMCPMC8819401
OpenAlexW4206755545

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.