Evidence map›Paper›PMID 35146134›Full record

ArticleBiochemistry and biophysics reports2022

Enhancement of proliferation of human umbilical cord blood-derived CD34

Yo Seph Park, Yukyeong Lee, Na Young Choi, Han Sung Hwang, Stefan Rose-John, Martin Zenke, Kinarm Ko

Abstract read
In one paragraph

Article in Biochemistry and biophysics reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yo Seph ParkDepartment of Stem Cell Biology, Konkuk University School of Medicine, Seoul, 05029, South Korea.
Yukyeong LeeDepartment of Stem Cell Biology, Konkuk University School of Medicine, Seoul, 05029, South Korea.
Na Young ChoiDepartment of Stem Cell Biology, Konkuk University School of Medicine, Seoul, 05029, South Korea.
Han Sung HwangDepartment of Obstetrics and Gynecology, Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, 05030, South Korea.
Stefan Rose-JohnInstitute of Biochemistry, Christian-Albrechts-University, Kiel, 24098, Germany.
Martin ZenkeDepartment of Cell Biology, Institute for Biomedical Engineering, RWTH Aachen University Medical School, Pauwelsstrasse 30, Aachen, 52074, Germany.
Kinarm KoDepartment of Stem Cell Biology, Konkuk University School of Medicine, Seoul, 05029, South Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Umbilical cord blood (UCB) is an alternative source of allogeneic hematopoietic stem cells (HSCs) for transplantation to treat various hematological disorders. The major limitation to the use of UCB-derived HSCs (UCB-HSCs) in transplantation, however, is the low numbers of HSCs in a unit of cord blood. To overcome this limitation, various cytokines or small molecules have been used to expand UCB-HSCs ex vivo. In this study, we investigated a synergistic effect of the combination of HIL-6, SR1, and UM171 on UCB-HSC culture and found that this combination resulted in the highest number of CD34

Indexed as

Hematopoietic stem cellsHyper-interleukin-6ProliferationSmall moleculeUmbilical cord blood

Identifiers

PMID35146134
PMCPMC8801758

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.