Evidence map›Paper›PMID 35146058›Full record

ArticleMovement disorders clinical practice2022

Current Guidelines for Classifying and Diagnosing Cervical Dystonia: Empirical Evidence and Recommendations.

Gamze Kilic-Berkmen, Sarah Pirio Richardson, Joel S Perlmutter, Mark Hallett, Christine Klein, Aparna Wagle-Shukla, Irene A Malaty, Stephen G Reich, Brian D Berman, Jeanne Feuerstein and 16 more

Open access · bronzeAbstract read
In one paragraph

Article in Movement disorders clinical practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Article
  4. Article
  5. Definition and Classification of Dystonia.Movement disorders : official journal of the Movement Disorder Society · 2025
    Review
  6. Dystonia: pathophysiology and the role of acupuncture in treatment.Wiener medizinische Wochenschrift (1946) · 2025
    Review
  7. Article
  8. Article
  9. Genetic Update and Treatment for Dystonia.International journal of molecular sciences · 2024
    Review
  10. Article
  11. Article
  12. Isolated Cervical Dystonia: Diagnosis and Classification.Movement disorders : official journal of the Movement Disorder Society · 2023
    Review
  13. Article
  14. Article
  15. What Is Hemidystonia?Movement disorders clinical practice · 2023
    Article
  16. Article
  17. Article
  18. Cervical Dystonia with Tremor: One Movement Disorder or Two?Movement disorders clinical practice · 2022
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 20 institutions in 4 countries.

Gamze Kilic-BerkmenDepartment of Neurology Emory University School of Medicine Atlanta Georgia USA.
Sarah Pirio RichardsonDepartment of Neurology University of New Mexico Health Sciences Center Albuquerque New Mexico USA.
Joel S PerlmutterDepartment of Neurology, Radiology, Neuroscience, Physical Therapy and Occupational Therapy Washington University School of Medicine St Louis Missouri USA.
Mark HallettHuman Motor Control Section, National Institute of Neurological Disorders and Stroke (NINDS) National Institute of Health (NIH) Bethesda Maryland USA.ORCID https://orcid.org/0000-0002-3180-6811
Christine KleinInstitute of Neurogenetics and Department of Neurology University of Luebeck and University Hospital of Schleswig-Holstein Luebeck Germany.
Aparna Wagle-ShuklaFixel Institute for Neurological Disease, University of Florida Department of Neurology University of Florida Gainesville Florida USA.
Irene A MalatyFixel Institute for Neurological Disease, University of Florida Department of Neurology University of Florida Gainesville Florida USA.ORCID https://orcid.org/0000-0001-6914-9223
Stephen G ReichDepartment of Neurology University of Maryland School of Medicine Baltimore Batimore Maryland USA.
Brian D BermanDepartment of Neurology Virginia Commonwealth University Richmond Virginia USA.ORCID https://orcid.org/0000-0002-0602-9942
Jeanne FeuersteinDepartment of Neurology University of Colorado Aurora Colorado USA.ORCID https://orcid.org/0000-0002-7701-3120
Marie VidailhetSorbonne University, Paris Brain Institute, Inserm, CNRS AP-HP, Salpetrière Hospital Paris France.ORCID https://orcid.org/0000-0002-2409-9143
Emmanuel RozeSorbonne University, Paris Brain Institute, Inserm, CNRS AP-HP, Salpetrière Hospital Paris France.
Joseph JankovicDepartment of Neurology, Parkinson's Disease Center and Movement Disorders Clinic Baylor College of Medicine Houston Texas USA.
Abhimanyu MahajanRush Parkinson's Disease and Movement Disorders Program, Department of Neurological Sciences Chicago Illinois USA.
Alberto J EspayJames J and Joan A Gardner Center for Parkinson's Disease and Movement Disorders University of Cincinnati Academic Health Center Cincinnati Ohio USA.
Richard L BarbanoDepartment of Neurology University of Rochester Rochester New York USA.
Mark S LeDouxDepartment of Psychology University of Memphis Memphis Tennessee USA.
Alexander PantelyatDepartment of Neurology Johns Hopkins University School of Medicine Batimore Maryland USA.ORCID https://orcid.org/0000-0002-6427-7485
Samuel FrankBeth Israel Deaconess Medical Center Harvard Medical School Boston Massachusetts USA.ORCID https://orcid.org/0000-0002-1866-162X
Natividad StoverDepartment of Neurology University of Alabama at Birmingham Birmingham Alabama USA.
Alfredo BerardelliDepartment of Human Neuroscience Sapienza University of Rome, Italy; IRCCS Neuromed Pozzilli Italy.ORCID https://orcid.org/0000-0003-3598-3142
Julie Leegwater-KimLahey Hospital and Medical Center Tufts University School Of Medicine Burlington Massachusetts USA.
Giovanni DefazioDepartment of Medical Sciences and Public Health University of Cagliari Cagliari Italy.
Scott A NorrisDepartment of Neurology and Radiology Washington University School of Medicine St. Louis Missouri USA.ORCID https://orcid.org/0000-0002-3835-0976
Hyder A JinnahDepartment of Neurology Emory University School of Medicine Atlanta Georgia USA.
Dystonia Coalition Investigators
Centre National de la Recherche Scientifique · FREmory University · USUniversity of Florida Health · USWashington University in St. Louis · USBaylor College of Medicine · USBeth Israel Deaconess Medical Center · USIstituto Neurologico Mediterraneo · ITJohns Hopkins University · USNational Institute of Neurological Disorders and Stroke · USRush University · USTufts University · USUniversity Hospital Schleswig-Holstein · DEUniversity of Alabama at Birmingham · USUniversity of Cagliari · ITUniversity of Cincinnati · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Maryland, Baltimore · USUniversity of Memphis · USUniversity of New Mexico · USUniversity of Rochester · US

Funding

Pathophysiology of Basal Ganglia DisordersZIANS003031 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI HALLETT, MARK · 2009 to 2023
$22.7M
Dystonia Coalition- Pilot ProjectU54NS116025 · NINDS · EMORY UNIVERSITY · PI JINNAH, HYDER A · 2019 to 2023
$7.1M
Dystonia CoalitionU54NS065701 · NINDS · EMORY UNIVERSITY · PI JINNAH, HYDER A · 2009 to 2014
$7.0M
Dystonia CoalitionU54TR001456 · NCATS · EMORY UNIVERSITY · PI JINNAH, HYDER A · 2015 to 2016
$2.5M
NCATS NIH HHS U54 TR001456NINDS NIH HHS U54 NS065701NINDS NIH HHS U54 NS116025
6 · The paper itself

Abstract

backgroundThe dystonias are phenotypically and etiologically heterogenous disorders. Many proposals and a consensus recommendation have been provided for the diagnosis and classification of the dystonias, but these recommendations serve only as general guidelines. Current diagnosis and classification may still depend on clinical judgment causing different opinions.

objectiveTo delineate clinical features used by movement disorder specialists in the diagnosis and classification of isolated focal cervical dystonia, and to develop recommendations for a more consistent approach to classification according to anatomical regions involved.

methodsCross-sectional data for subjects diagnosed with isolated dystonia were acquired from the Dystonia Coalition, an international, multicenter collaborative research network. Data from many movement disorder specialists were evaluated to determine how diagnoses of cervical dystonia related to their recorded examinations. Cases were included if they were given a diagnosis of focal cervical dystonia. Cases were also included if they had dystonia of the neck on exam, but were given an alternative diagnosis such as segmental dystonia.

resultsAmong 2916 subjects with isolated dystonia, 1258 were diagnosed with focal cervical dystonia. Among these 1258 cases, 28.3% had dystonia outside of the neck region. Regions involved outside of the neck included the shoulder, larynx, and sometimes other regions. Analysis of the results pointed to several factors that may influence specialists' use of current diagnostic guidelines for making a diagnosis of isolated focal cervical dystonia including varied interpretations of involvement of nearby regions (shoulder, larynx, platysma), severity of dystonia across different regions, and occurrence of tremor in different regions.

conclusionsAlthough focal cervical dystonia is the most common type of dystonia, a high percentage of subjects given this diagnosis had dystonia outside of the neck region. This observation points to the need for more specific guidelines for defining this common disorder. Such guidelines are proposed here.

Indexed as

cervical dystoniaclassificationdiagnosisdiagnostic criteriatorticollis

Identifiers

PMID35146058
PMCPMC8810420
OpenAlexW3214447239

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.