Evidence map›Paper›PMID 35146050›Full record

ArticleOpen forum infectious diseases2022

Herpes Zoster Following Recombinant Zoster Vaccine With or Without Concomitant Vaccination.

Katia J Bruxvoort, Lei Qian, Jun Wu, Ana Florea, Bradley Ackerson, Lina S Sy, Leticia Vega Daily, Harpreet Takhar, Hung Fu Tseng

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Katia J BruxvoortDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.ORCID https://orcid.org/0000-0001-8277-2431
Lei QianDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.
Jun WuDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.
Ana FloreaDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.
Bradley AckersonDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.
Lina S SyDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.ORCID https://orcid.org/0000-0003-2762-9266
Leticia Vega DailyDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.
Harpreet TakharDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.
Hung Fu TsengDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.
Kaiser Permanente · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe 2-dose recombinant zoster vaccine (RZV) series is recommended for prevention of herpes zoster (HZ) in adults aged ≥50 years, but data are limited on the impact of concomitant administration with other vaccines on subsequent HZ risk.

methodsThis cohort study included Kaiser Permanente Southern California members aged ≥50 years who received 2 doses of RZV 4 weeks to ≤6 months apart during 1 April 2018-30 September 2019. RZV recipients with and without same-day concomitant vaccination for either RZV dose were followed up for incident HZ beginning 31 days after the second RZV dose until 30 September 2020. The hazard ratio (HR) for HZ comparing RZV recipients with and without concomitant vaccination was estimated using Cox proportional hazards regression, adjusting for confounders.

resultsRZV with and without concomitant vaccination was received by 12 898 and 28 353 individuals, respectively. HZ occurred among 41 individuals with concomitant vaccination (incidence rate, 2.2 [95% confidence interval {CI}, 1.6-3.0] per 1000 person-years) and 136 without concomitant vaccination (3.4 [95% CI, 2.9-4.0] per 1000 person-years). The adjusted HR for HZ comparing RZV recipients with and without concomitant vaccination was 0.75 (95% CI, .53-1.08).

conclusionsHZ risk was not significantly different between RZV recipients with and without concomitant vaccination, supporting recommendations allowing for concomitant administration of RZV with other vaccines.

Indexed as

concomitant vaccinationherpes zosterreal-world datarecombinant zoster vaccinesimultaneous vaccination

Identifiers

PMID35146050
PMCPMC8825562
OpenAlexW4210923738

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.