Evidence map›Paper›PMID 35145925›Full record

ArticleFrontiers in cellular and infection microbiology2021

Extracellular Vesicles Generated by Gram-Positive Bacteria Protect Human Tissues

Paolo E Costantini, Christophe Vanpouille, Andrea Firrincieli, Martina Cappelletti, Leonid Margolis, Rogers A Ñahui Palomino

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 28 citations in OpenAlex.

  1. Virulence · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. mSystems · 2025
    Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Immunomodulatory properties ofFrontiers in immunology · 2024
    Article
  16. Use of probiotic lactobacilli in the treatment of vaginal infections:Frontiers in cellular and infection microbiology · 2023
    Review
  17. Interactions between microbiota and cervical epithelial, immune, and mucus barrier.Frontiers in cellular and infection microbiology · 2023
    Review
  18. Review
  19. Review
  20. Extracellular vesicles in reproduction and pregnancy.Extracellular vesicles and circulating nucleic acids · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Paolo E CostantiniSection of Intercellular Interaction, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.
Christophe VanpouilleSection of Intercellular Interaction, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.
Andrea FirrincieliDepartment of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
Martina CappellettiDepartment of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
Leonid MargolisSection of Intercellular Interaction, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.
Rogers A Ñahui PalominoSection of Intercellular Interaction, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.
Eunice Kennedy Shriver National Institute of Child Health and Human Development · USUniversity of Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaginal microbiota dominated by lactobacilli protects women from sexually transmitted infection, in particular HIV-1. This protection is, in part, mediated by

Indexed as

Extracellular VesiclesHIV-1MicrobiotaFemaleGardnerella vaginalisHumansLactobacillusEnteroccoccus faecalisEnteroccoccus faeciumextracellular vesicles (EVs)Gardnerella vaginalisgram positive bacteriaHIV-1Staphylocccus aureusvaginal microbiota

Identifiers

PMID35145925
PMCPMC8821821
OpenAlexW4210611829

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.