Evidence map›Paper›PMID 35145650›Full record

ArticleClinical kidney journal2022

Crystalline podocytopathy and tubulopathy linked to kappa light chain deposits in a context of smoldering multiple myeloma.

Sébastien Eymieux, Elodie Miquelestorena-Standley, Nolwenn Rabot, Valentin Maisons, Guy Touchard, Emmanuelle Blanchard

Abstract read
In one paragraph

Article in Clinical kidney journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sébastien EymieuxUnité de Biologie cellulaire et microscopie électronique, hôpital Bretonneau CHRU de Tours, Tours, France.ORCID https://orcid.org/0000-0002-4738-510X
Elodie Miquelestorena-StandleyService d'Anatomie et Cytologie Pathologiques, CHRU de Tours, Tours, France.ORCID https://orcid.org/0000-0002-6375-3734
Nolwenn RabotService de Néphrologie, CHRU Tours, Tours, France.
Valentin MaisonsEA4245-Transplantation, Immunologie, Inflammation, Université de Tours, Tours, France.
Guy TouchardService d'Anatomie et Cytologie Pathologiques, CHRU Poitiers, Poitiers, France.
Emmanuelle BlanchardUnité de Biologie cellulaire et microscopie électronique, hôpital Bretonneau CHRU de Tours, Tours, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 42-year-old man with smoldering immunoglobulin G kappa multiple myeloma showed a heavy proteinuria composed of free light chain, prompting performance of a kidney biopsy. Electron microscopy revealed numerous rhomboid-shaped crystals labelled by the anti-kappa in immunogold, notably in the cytoplasm of podocytes, establishing the diagnosis of crystalline podocytopathy. This case illustrates a rare form of monoclonal gammopathy of renal significance, and highlights the key role of electron microscopy and immunogold to better elucidate the location and composition of crystals.

Indexed as

crystalselectron microscopyimmunogoldlight chainMGRSmyelomapodocytopathy

Identifiers

PMID35145650
PMCPMC8824780

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.