Evidence map›Paper›PMID 35145570›Full record

ArticleBiomicrofluidics2022

Robotic automation of droplet microfluidics.

Tuan M Tran, Samuel C Kim, Cyrus Modavi, Adam R Abate

Open access · hybridAbstract read
In one paragraph

Article in Biomicrofluidics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Tuan M TranDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California 94158, USA.
Samuel C KimDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California 94158, USA.ORCID 0000-0001-5237-6358
Cyrus ModaviDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California 94158, USA.
University of California, San Francisco · USQB3 · US

Funding

Gigapixel digital PCR in Giant Unilamellar VesiclesR01EB019453 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ABATE, ADAM R., CHIU, CHARLES YEN · 2014 to 2022
$3.9M
Microfluidic immunoprofiling for biomarker discovery in rheumatoid arthritisDP2AR068129 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ABATE, ADAM R. · 2014 to 2014
$2.4M
Accurate and unbiased single cell sequencing with digital droplet MDAR01HG008978 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ABATE, ADAM R. · 2016 to 2018
$1.9M
Evaluating HIV expression and latency in blood and tissues at the single cell levelR21AI116218 · NIAID · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI WONG, JOSEPH K · 2014 to 2015
$442k
Accurate, long-read sequencing with droplet-microfluidic barcodingR21HG007233 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ABATE, ADAM R., HERNANDEZ, RYAN D. · 2013 to 2014
$433k
NHGRI NIH HHS R01 HG008978NHGRI NIH HHS R21 HG007233NIAID NIH HHS R21 AI116218NIAMS NIH HHS DP2 AR068129NIBIB NIH HHS R01 EB019453
6 · The paper itself

Abstract

Droplet microfluidics enables powerful analytic capabilities but often requires workflows involving macro- and microfluidic processing steps that are cumbersome to perform manually. Here, we demonstrate the automation of droplet microfluidics with commercial fluid-handling robotics. The workflows incorporate common microfluidic devices including droplet generators, mergers, and sorters and utilize the robot's native capabilities for thermal control, incubation, and plate scanning. The ability to automate microfluidic devices using commercial fluid handling will speed up the integration of these methods into biological workflows.

Identifiers

PMID35145570
PMCPMC8816516
OpenAlexW4210440864

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.