ArticleFrontiers in endocrinology2021
Features of Lymph Node Metastasis and Structural Recurrence in Papillary Thyroid Carcinoma Located in the Upper Portion of the Thyroid: A Retrospective Cohort Study.
Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of the effect and clinical significance of Delphian lymph node metastasis in papillary thyroid cancer.Frontiers in endocrinology · 2023Pooled it
- Organoid modeling identifies EDN1 as a potential oncogenic driver in papillary thyroid carcinoma via modulation of the Hippo-YAP signaling pathway.Journal of endocrinological investigation · 2026Article
- Machine learning-based prediction of lymph node metastasis in papillary thyroid carcinoma: an interpretable multidimensional model.Frontiers in endocrinology · 2026Article
- Development and validation of an interpretable machine learning model for predicting central lymph node metastasis in papillary thyroid cancer.Frontiers in oncology · 2026Article
- Internal validation of a residual thyroid recurrence model after PTC.Frontiers in oncology · 2026Article
- Synchronous metastatic differentiated high-grade thyroid carcinoma in lymph node from classic papillary thyroid carcinoma: a case report and literature review.Frontiers in oncology · 2026Article
- The value of ultrasonographic scoring method and nomogram in assessing cervical lymph node metastasis of papillary thyroid carcinoma.Thyroid research · 2025Article
- Positive preoperative circulating tumor cells level associated with lymph node metastasis in papillary thyroid carcinoma patients with capsular invasion.World journal of surgical oncology · 2025Article
- A retrospective study of 17,995 patients investigating the location and recurrence of papillary thyroid cancer.Scientific reports · 2025Article
- Risk factors for cervical lymph node metastasis at different lateral levels in papillary thyroid cancer: level III as the central hub.Gland surgery · 2024Article
- Risk factors analysis of lateral cervical lymph node metastasis in papillary thyroid carcinoma: a retrospective study of 830 patients.World journal of surgical oncology · 2024Article
- Analysis of risk factors for lateral lymph node metastasis in T1 stage papillary thyroid carcinoma: a retrospective cohort study.Gland surgery · 2024Article
- Risk factors for cervical lymph node metastasis of papillary thyroid cancer in elderly patients aged 65 and older.Frontiers in endocrinology · 2024Article
- A comprehensive prediction model for central lymph node metastasis in papillary thyroid carcinoma with Hashimoto's thyroiditis: BRAF may not be a valuable predictor.Frontiers in endocrinology · 2024Article
- Assessing the role of central lymph node ratio in predicting recurrence in N1a low-to-intermediate risk papillary thyroid carcinoma.Frontiers in endocrinology · 2023Article
- The optimal extent of lymph node dissection in N1b papillary thyroid microcarcinoma based on clinicopathological factors and preoperative ultrasonography.Gland surgery · 2022Article
- Nomograms for the prediction of lateral lymph node metastasis in papillary thyroid carcinoma: Stratification by size.Frontiers in oncology · 2022Article
- Machine learning-based dynamic prediction of lateral lymph node metastasis in patients with papillary thyroid cancer.Frontiers in endocrinology · 2022Article
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6 authors.
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Abstract
Background: This study aims to reveal the features of lymph node metastasis (LNM) and recurrence in papillary thyroid carcinoma (PTC) tumors located in the upper portion of the thyroid. Methods: A total of 1075 PTC patients were retrospectively reviewed, including 314 patients with a tumor in the upper portion of the thyroid. Another 103 PTC patients with upper portion diagonsis from three clinical centers were included for external validation. Results: The results showed no difference between the patients with a tumor in the upper portion of the thyroid and those with a tumor in the non-upper portion in terms of overall LNM rates. However, patients with a tumor in the upper portion were significantly more prone to LLNM and exhibited a significantly worse recurrence outcome than those with a tumor in other subregions. Multivariate analysis showed that four factors-age no more than 40, maximum tumor diameter no less than1.0 cm, the presence of thyroid capsular invasion, and tumor with ipsilateral nodular goiter-were independent risk factors for LLNM of the tumor in the upper thyroid. A predictive risk-scoring model was established based on these factors. Conclusions: Patients with PTC located in the upper portion may have an exclusive lymphatic drainage pathway to the lateral neck region and are more prone to suffer from LLNM and tumor recurrence than those with a tumor located in other subregions. A new postoperative strategy selection flow chart was established based on our newly created risk-scoring model that can effectively predict the individualized possibility of LLNM for PTC patients with a tumor in the upper portion.
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