Evidence map›Paper›PMID 35145374›Full record

ArticleFrontiers in neuroscience2021

Association of Epigenetic Differences Screened in a Few Cases of Monozygotic Twins Discordant for Attention-Deficit Hyperactivity Disorder With Brain Structures.

Takashi X Fujisawa, Shota Nishitani, Kai Makita, Akiko Yao, Shinichiro Takiguchi, Shoko Hamamura, Koji Shimada, Hidehiko Okazawa, Hideo Matsuzaki, Akemi Tomoda

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Takashi X FujisawaResearch Center for Child Mental Development, University of Fukui, Fukui, Japan.
Shota NishitaniResearch Center for Child Mental Development, University of Fukui, Fukui, Japan.
Kai MakitaResearch Center for Child Mental Development, University of Fukui, Fukui, Japan.
Akiko YaoResearch Center for Child Mental Development, University of Fukui, Fukui, Japan.
Shinichiro TakiguchiDepartment of Child and Adolescent Psychological Medicine, University of Fukui Hospital, Fukui, Japan.
Shoko HamamuraDivision of Developmental Higher Brain Functions, United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University, and University of Fukui, Osaka, Japan.
Koji ShimadaResearch Center for Child Mental Development, University of Fukui, Fukui, Japan.
Hidehiko OkazawaResearch Center for Child Mental Development, University of Fukui, Fukui, Japan.
Hideo MatsuzakiResearch Center for Child Mental Development, University of Fukui, Fukui, Japan.
Akemi TomodaResearch Center for Child Mental Development, University of Fukui, Fukui, Japan.
Hamamatsu University School of Medicine · JPKanazawa University · JPOsaka University · JPUniversity of Fukui Hospital · JPChiba University · JPUniversity of Fukui · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study examined the relationship between DNA methylation differences and variations in brain structures involved in the development of attention-deficit hyperactivity disorder (ADHD). First, we used monozygotic (MZ) twins discordant (2 pairs of 4 individuals, 2 boys, mean age 12.5 years) for ADHD to identify candidate DNA methylation sites involved in the development of ADHD. Next, we tried to replicate these candidates in a case-control study (ADHD:

Indexed as

attention-deficit hyperactivity disorder (ADHD)DNA methylationmonozygotic twinsSorCS2voxel-based morphometry (VBM)

Identifiers

PMID35145374
PMCPMC8823258
OpenAlexW4207029879

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.