ArticleNature cell biology2022
METTL16 exerts an m
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Article in Nature cell biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 238 papers.
0numbers the graph read from it
0cells of the map it votes in
238citing papers in PubMed
30.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
238 citing papers in PubMed, 338 citations in OpenAlex.
- METTL18-catalyzed histidine methylation of YTHDF2 promotes mRNA stability.Science China. Life sciences · 2026Article
- Cuproptosis: potential new direction in liver-related diseases research and treatment.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- Review
- METTL16 S-glutathionylation-triggered RNA mActa pharmacologica Sinica · 2026Article
- The mitochondria enzyme OGDH defends against disulfidptosis by licensing METTL3-regulated NRF2 translation.Nature cell biology · 2026Article
- Role of the m6A methyltransferase Mettl16 in Drosophila development.PLoS genetics · 2026Article
- Targeting Copper in Cancer: Chelators to Counteract Cuproplasia and Ionophores to Promote Cuproptosis.Journal of medicinal chemistry · 2026Review
- The Role of NMedComm · 2026Review
- Nuclear mNature chemical biology · 2026Article
- METTL16 Promotes Head and Neck Squamous Cell Carcinoma Progression via m6A-Mediated Stabilization of SREBP2 mRNA and Enhanced Cholesterol Biosynthesis.Cancer medicine · 2026Article
- The role of m6A modification in spermatogenic dysfunction.Molecular biology reports · 2026Review
- Endothelial USP2a-METTL16 loop potentiates IL-6 signaling via mCell death and differentiation · 2026Article
- Uncovering a role for METTL13 in malignant transformation of human hematopoietic stem cells and in the progression of pediatric leukemia.Cell death & disease · 2026Article
- YTHDC1 recognizes METTL16-dependent mProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Isoform-specific m6A deposition and coordinated splicing shape mammalian transcriptome evolution.Nature communications · 2026Article
- METTL16 promotes MASLD progression through the regulation of lipid synthesis and immune response.Biology direct · 2026Article
- Article
- Integrated single-cell and bulk transcriptomics reveals an IGF2BP3-driven metabolic circuitry in endometrial cancer.BMC cancer · 2026Article
- Male germ cell-specific deletion ofZoological research · 2026Article
- The eIF3a/m6A/ENO1 axis orchestrates glycolytic reprogramming and cell growth in cervical cancer.Journal of bioenergetics and biomembranes · 2026Article
178 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
32 authors at 8 institutions in 2 countries.
Rui Su *Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA. rsu@coh.org.ORCID http://orcid.org/0000-0002-4807-6229
Lei Dong *Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA.
Yangchan Li *Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA.
Min Gao *Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA.
P Cody He *Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA.
Wei Liu *Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA.
Jiangbo WeiDepartment of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-2691-6490
Zhicong ZhaoDepartment of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA.
Lei GaoDepartment of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA.
Li HanDepartment of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA.
Xiaolan DengDepartment of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA.
Chenying LiDepartment of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA.
Emily PrinceDepartment of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA.
Brandon TanDepartment of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA.
Ying QingDepartment of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA.ORCID http://orcid.org/0000-0001-6763-6204
Xi QinDepartment of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA.
Chao ShenDepartment of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA.
Meilin XueDepartment of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA.
Keren ZhouDepartment of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA.
Zhenhua ChenDepartment of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA.
Jianhuang XueDepartment of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA.
Wei LiDepartment of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA.
Hanjun QinThe Integrative Genomics Core, Beckman Research Institute of City of Hope, Duarte, CA, USA.
Xiwei WuThe Integrative Genomics Core, Beckman Research Institute of City of Hope, Duarte, CA, USA.
Miao SunKeck School of Medicine, University of Southern California, and Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Yunsun NamLaboratory of RNA Biology, Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-7939-8626
Chun-Wei ChenDepartment of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA.ORCID http://orcid.org/0000-0002-8737-6830
Wendong HuangDepartment of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, Beckman Research Institute of City of Hope, Duarte, CA, USA.ORCID http://orcid.org/0000-0003-3735-9466
David HorneCity of Hope Comprehensive Cancer Center, City of Hope, Duarte, CA, USA.
Steven T RosenCity of Hope Comprehensive Cancer Center, City of Hope, Duarte, CA, USA.
Chuan HeDepartment of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA. chuanhe@uchicago.edu.ORCID http://orcid.org/0000-0003-4319-7424
Jianjun ChenDepartment of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA. jianchen@coh.org.ORCID http://orcid.org/0000-0003-3749-2902
City of Hope · USHoward Hughes Medical Institute · USHebei Medical University · CNJiangnan University · CNShanghai Jiao Tong University · CNSun Yat-sen University · CNThe University of Texas Southwestern Medical Center · USUniversity of Southern California · US
Funding
Transcriptome-wide base-resolution sequencing of pseudouridine in human normal and AD brain tissues-CEGS Admin supplement 2020-2021RM1HG008935 · NHGRI · UNIVERSITY OF CHICAGO · PI HE, CHUAN · 2016 to 2025
$24.4MRuth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32)T32HD007009 · NICHD · UNIVERSITY OF CHICAGO · PI NANCY B SCHWARTZ · 1985 to 2026
$13.0MMiRNAs in hepatocellular carcinoma development and treatmentR01CA139158 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI HUANG, WENDONG, YU, HUA E · 2011 to 2021
$3.7MThe role and therapeutic potential of IGF2BP2 in MLL-rearranged leukemiaR01CA271497 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Jianjun Chen · 2022 to 2026
$2.8MTargeting FTO to treat acute myeloid leukemiaR01CA243386 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI CHEN, JIANJUN · 2020 to 2024
$2.8MRecognition and mechanism of N6-methyl adenosine modificationsR01GM113194 · NIGMS · UNIVERSITY OF CHICAGO · PI PAN, TAO · 2015 to 2022
$2.5MThe role and mechanism of METTL3/METTL14-mediated RNA modification in the pathogenesis and drug-resistance of AMLR01CA236399 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI CHEN, JIANJUN · 2019 to 2023
$2.3MTargeting TET1 signaling to treat acute myeloid leukemiaR01CA211614 · NCI · UNIVERSITY OF CINCINNATI · PI CHEN, JIANJUN · 2017 to 2021
$2.3MThe function and underlying mechanism of TET1 in myelodysplastic syndromesR01DK124116 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI CHEN, JIANJUN · 2020 to 2023
$2.2MThe role and mechanism of FTO in leukemogenesis and drug responseR01CA214965 · NCI · UNIVERSITY OF CINCINNATI · PI CHEN, JIANJUN · 2017 to 2021
$2.1MDNA Damage Response and Oncogenic SignalingT32CA186895 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI BINGHUI SHEN, Jeremy Michael Stark · 2016 to 2026
$2.1MBile acids and metabolic surgeryR01DK124627 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI HUANG, WENDONG · 2020 to 2024
$2.0MHoward Hughes Medical InstituteNCI NIH HHS R01 CA139158NCI NIH HHS R01 CA211614NCI NIH HHS R01 CA214965NCI NIH HHS R01 CA236399NCI NIH HHS R01 CA243386NCI NIH HHS R01 CA271497NCI NIH HHS T32 CA186895NHGRI NIH HHS RM1 HG008935NICHD NIH HHS T32 HD007009NIDDK NIH HHS R01 DK124116NIDDK NIH HHS R01 DK124627NIDDK NIH HHS R56 DK120282NIGMS NIH HHS R01 GM088599NIGMS NIH HHS R01 GM113194
Abstract
METTL16 has recently been identified as an RNA methyltransferase responsible for the deposition of N
Indexed as
Protein BiosynthesisRNA Processing, Post-TranscriptionalAdenosineAnimalsCarcinogenesisCarcinoma, HepatocellularCytosolEukaryotic Initiation Factor-3Gene Expression Regulation, NeoplasticHEK293 CellsHep G2 CellsHumansLiver NeoplasmsMethyltransferasesMiceMice, Inbred NODAdenosineEIF3A protein, humanEIF3B protein, humanEukaryotic Initiation Factor-3MethyltransferasesMETTL16 protein, humanN-methyladenosineRNA, MessengerRNA, Ribosomal
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