ArticleScientific reports2022
Persistent susceptibility of Aedes aegypti to eugenol.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Efficacy of a eugenol-based nanoemulsion formulation incorporating a mosquitocidal Lysinibacillus sp. strain VCRC B654 against Culex quinquefasciatus under laboratory and simulated field conditions.Archives of microbiology · 2026Article
- Effects ofPathogens (Basel, Switzerland) · 2026Article
- Ocimum basilicum essential oil controls Haemaphysalis longicornis via multi-modal toxicity, enzyme inhibition, and synergy with hexythiazox.BMC veterinary research · 2026Article
- Encapsulated essential oil-based nanoemulsion beads: a green innovation for storage pest control againstRSC advances · 2026Article
- Essential Oils for Flea and Tick Control in Companion Animals: A Critical Review of Efficacy, Safety, Resistance Mitigation and Integrated Pest Management.Antibiotics (Basel, Switzerland) · 2026Review
- Exploratory Review on Male Fertility Potential of Acetyl-Eugenol: Mechanistic Insights, Experimental Evidence, and Therapeutic Prospects.Journal of experimental pharmacology · 2026Review
- Review
- Larvicidal Potential ofPharmaceuticals (Basel, Switzerland) · 2025Article
- [Effects of larval feeding amount on development and deltamethrin resistance inNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025Article
- The low-lethal concentrations of rotenone and pyrethrins suppress the population growth of Rhopalosiphum padi.Scientific reports · 2024Article
- Bioactivity of Eugenol: A Potential Antibiotic Adjuvant with Minimal Ecotoxicological Impact.International journal of molecular sciences · 2024Article
- Urbanization and Water Containers Influence the Mosquito Community with Consequences for Aedes aegypti.Neotropical entomology · 2024Article
- Do combinations of fipronil, eugenol and carvacrol have synergistic effects against Rhipicephalus sanguineus?Parasitology research · 2023Article
- Novel paradigm of mosquito-borne disease control based on self-powered strategy.Frontiers in public health · 2023Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Botanical insecticides are preferred for their environment and user-friendly nature. Eugenol is a plant-based monoterpene having multifarious biocidal activities. To understand whether eugenol would persistently work against Aedes aegypti, we performed larvicidal bioassays on thirty successive generations and determined median lethal concentration (LC50) on each generation. Results showed no apparent differences between LC50 at F0 (63.48 ppm) and F30 (64.50 ppm) indicating no alteration of susceptibility toward eugenol. To analyze, if eugenol has any effect on metabolic detoxification-associated enzymes, we measured esterases (alpha and beta), cytochrome P450, and GST activities from the survived larvae exposed to LC50 concentration from F0-F30. Results revealed a decrease of esterases, GST, and cytochrome P450 activities at the initial 4-8 generations and then a gradual increase as the generations progressed. GST activity remained significantly below the control groups. Synergists (TPP, DEM, and PBO) were applied along with eugenol at F30 and LC50 concentration, and the said enzyme activities were recorded. Results showed a noticeable decrease in LC50 and enzyme activities indicating effective inhibitions of the respective enzymes. Overall, present results inferred that eugenol would effectively work as a larvicide for a longer period in successive generations without initiating rapid resistance and therefore could be advocated for controlling A. aegypti.
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