ArticleScientific reports2022
Selection of new diagnostic markers for Dirofilaria repens infections with the use of phage display technology.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Circulation ofLife (Basel, Switzerland) · 2025Article
- Molecular investigation of Dirofilaria repens, Dirofilaria immitis and Acanthocheilonema reconditum in stray dogs and cats in Ukraine.BMC veterinary research · 2025Article
- Zoonotic filariasis and its public health significance: a comprehensive literature review.Frontiers in microbiology · 2025Review
- Analysis of the role ofJournal of veterinary research · 2024Article
- Molecular insights and antibody response to Dr20/22 in dogs naturally infected with Dirofilaria repens.Scientific reports · 2024Article
- An unexpected case of a dog from Poland co-infected with Dirofilaria repens and Dirofilaria Immitis.BMC veterinary research · 2024Article
- Evolution of dirofilariasis diagnostic techniques from traditional morphological analysis to molecular-based techniques: a comprehensive review.Frontiers in parasitology · 2024Review
- Epitopes and Mimotopes Identification Using Phage Display for Vaccine Development against Infectious Pathogens.Vaccines · 2023Review
- Subcutaneous Dirofilariosis of the Eyelid Brought to Poland from the Endemic Territory of Ukraine.Pathogens (Basel, Switzerland) · 2023Article
- The long-distance relationship betweenFrontiers in veterinary science · 2023Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dirofilaria repens is a parasitic nematode causing vector-borne disease (dirofilariasis), considered an emerging problem in veterinary and human medicine. Although main hosts are carnivores, particularly dogs, D. repens shows high zoonotic potential. The disease spreads uncontrollably, affecting new areas. Since there is no vaccine against dirofilariasis, the only way to limit disease transmission is an early diagnosis. Currently, diagnosis depends on the detection of microfilariae in the host bloodstream using modified Knott's test or multiplex PCR. However, the efficacy of tests relying on microfilariae detection is limited by microfilariae periodic occurrence. Therefore, a new reliable diagnostic test is required. Our study aimed to select new diagnostic markers for dirofilariasis with potential application in diagnostics. We focused on single epitopes to ensure high specificity of diagnosis and avoid cross-reactivity with the other parasite infections common in dogs. Using phage display technology and 12-mer peptides library, we selected epitopes highly reactive with IgG from sera of infected dogs. Additionally, our study presents the possibility of detecting D. repens specific cell-free DNA in dogs with no microfilaria but high IgG and IgM antibody levels against parasite somatic antigen.
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