ArticleNature communications2022
Superior Colliculus to VTA pathway controls orienting response and influences social interaction in mice.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Article
- A novel superior colliculus circuit mediates visual cue-driven methamphetamine taking and seeking.Acta pharmacologica Sinica · 2026Article
- Midbrain endocannabinoids actuate dopamine-based action selection.Cell reports · 2026Article
- A collicular-hypothalamic pathway for social visual awareness.bioRxiv : the preprint server for biology · 2026Article
- Pupillometry and brain-wide c-Fos mapping uncover multimodal mirror emotional contagion related networks of mice.iScience · 2026Article
- Anatomical and functional examination of superior colliculus projections to the inferior olivary in mice.Brain structure & function · 2025Article
- Serum Cocaine- and Amphetamine-Regulated Transcript Levels and Cooperativeness in Adolescents With Internet Gaming Disorder.Psychiatry investigation · 2025Article
- Superior Colliculus Projections Drive Dopamine Neuron Activity and Movement But Not Value.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Superior colliculus projections drive dopamine neuron activity and movement but not value.bioRxiv : the preprint server for biology · 2025Article
- Potentiation of Nigra-Striatal Dopaminergic Projection Underpins Core Autism-Like Behaviors in Valproate-Exposed Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Translational research approach to social orienting deficits in autism: the role of superior colliculus-ventral tegmental pathway.Molecular psychiatry · 2025Article
- Fear Synchrony of Mouse Dyads: Interaction of Sex Composition and Stress.Biological psychiatry global open science · 2025Article
- A cell-type-specific epigenetic mechanism encodes social investigatory behavior via Lrhcn1 and Hcn1.Science advances · 2025Article
- Article
- Superior Colliculus Controls the Activity of the Substantia Nigra Pars Compacta and Ventral Tegmental Area in an Asymmetrical Manner.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A superior colliculus-originating circuit prevents cocaine reinstatement via VR-based eye movement desensitization treatment.National science review · 2025Article
- Vitamin A attenuates PFOS-induced neurotoxicity and alters early proximity patterns to conspecifics in zebrafish larvae.Frontiers in behavioral neuroscience · 2025Article
- Examining the role of the photopigment melanopsin in the striatal dopamine response to light.Frontiers in systems neuroscience · 2025Article
- Pre-existing visual responses in a projection-defined dopamine population explain individual learning trajectories.Current biology : CB · 2024Article
- Monosynaptic Inputs to Ventral Tegmental Area Glutamate and GABA Co-transmitting Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Social behaviours characterize cooperative, mutualistic, aggressive or parental interactions that occur among conspecifics. Although the Ventral Tegmental Area (VTA) has been identified as a key substrate for social behaviours, the input and output pathways dedicated to specific aspects of conspecific interaction remain understudied. Here, in male mice, we investigated the activity and function of two distinct VTA inputs from superior colliculus (SC-VTA) and medial prefrontal cortex (mPFC-VTA). We observed that SC-VTA neurons display social interaction anticipatory calcium activity, which correlates with orienting responses towards an unfamiliar conspecific. In contrast, mPFC-VTA neuron population activity increases after initiation of the social contact. While protracted phasic stimulation of SC-VTA pathway promotes head/body movements and decreases social interaction, inhibition of this pathway increases social interaction. Here, we found that SC afferents mainly target a subpopulation of dorsolateral striatum (DLS)-projecting VTA dopamine (DA) neurons (VTA
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