ArticleNature communications2022
Mark-release-recapture experiment in Burkina Faso demonstrates reduced fitness and dispersal of genetically-modified sterile malaria mosquitoes.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Engineering resilient gene drives for sustainable malaria control by predicting, testing and overcoming target site resistance in Anopheles gambiae.PLoS biology · 2026Article
- Population size and dispersal of Anopheles coluzzii on São Tomé and Príncipe Islands based on mark-release-recapture.Journal of medical entomology · 2026Article
- Age-grading and species identification of male mosquito Anopheles gambiae s.l. using mid-infrared spectroscopy and machine learning.Scientific reports · 2026Article
- Knowledge, perspectives, and risk perceptions on gene drive and genetically modified mosquitoes for malaria control among African stakeholders: a scoping review protocol.Systematic reviews · 2026Article
- RDA-PSO: A Computational Method to Quantify the Diffusive Dispersal of Insects.Bulletin of mathematical biology · 2026Article
- Ecological analysis of mosquito larval communities in Burkina Faso to inform environmental monitoring of genetic control programs.Scientific reports · 2026Article
- Microsatellite analysis of genetic differentiation among populations of the malaria vector Anopheles funestus across mainland Tanzania reveals contrasted patterns of geographic isolation and gene flow.Parasites & vectors · 2026Article
- Extended time to maturity in Anopheles coluzzii: Implications of late egg hatch for vector control and transgene fitness.Medical and veterinary entomology · 2025Article
- Requirements for designing cluster randomised control trials to detect suppression of malaria vector population densities.BMC biology · 2025Article
- The estrobolome: Estrogen-metabolizing pathways of the gut microbiome and their relation to breast cancer.International journal of cancer · 2025Review
- CRISPR technologies for the control and study of malaria-transmitting anopheline mosquitoes.Parasites & vectors · 2025Review
- Influence of genetic factors of humans, mosquitoes and parasites, on the evolution of Plasmodium falciparum infections, malaria transmission and genetic control methods: a review of the literature.BMC medical genomics · 2025Review
- Age structure and parity status determination of Afrotropical malaria vectors using MALDI-TOF MS.Scientific reports · 2025Article
- Article
- Maximizing horizontal transmission through mating: increased mating frequency and mating competitiveness associated with Microsporidia MB-infected Anopheles arabiensis males.Malaria journal · 2025Article
- Screening the Resistance of MaleInsects · 2025Article
- Gene drives: an alternative approach to malaria control?Gene therapy · 2025Review
- Emerging technologies transforming the future of global biosecurity.Frontiers in digital health · 2025Review
- Article
- Procedural legitimacy: co-developing a community agreement model for genetic approaches research to malaria control in Africa.Malaria journal · 2024Article
Corrections and comments
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Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Every year, malaria kills approximately 405,000 people in Sub-Saharan Africa, most of them children under the age of five years. In many countries, progress in malaria control has been threatened by the rapid spread of resistance to antimalarial drugs and insecticides. Novel genetic mosquito control approaches could play an important role in future integrated malaria control strategies. In July 2019, the Target Malaria consortium proceeded with the first release of hemizygous genetically-modified (GM) sterile and non-transgenic sibling males of the malaria mosquito Anopheles coluzzii in Burkina Faso. This study aimed to determine the potential fitness cost associated to the transgene and gather important information related to the dynamic of transgene-carrying mosquitoes, crucial for next development steps. Bayesian estimations confirmed that GM males had lower survival and were less mobile than their wild type (WT) siblings. The estimated male population size in Bana village, at the time of the release was 28,000 - 37,000. These results provide unique information about the fitness and behaviour of released GM males that will inform future releases of more effective strains of the A. gambiae complex.
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