ArticleNature communications2022
Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes.
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Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
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Who cites it
30 citing papers in PubMed, 44 citations in OpenAlex.
- State-dependent inhibition of LRRC8 volume-regulated anion channels by DCPIB.The Journal of general physiology · 2026Article
- Unraveling the role of FGF21 in epilepsy disease: mechanistic insights and therapeutic Potential.Metabolic brain disease · 2026Review
- Structures of the volume-regulated anion channel LRRC8A/D in activating and inhibiting conditions.Nature communications · 2026Article
- The intracellular subdomain of the volume-regulated anion channel subunit LRRC8A is a hotspot of channel activation.Nature communications · 2026Article
- Binding to Albumin and Off-Target Toxicity Confound the Use of LRRC8/VRAC Channel Blockers in Cell Physiology Assays.bioRxiv : the preprint server for biology · 2026Article
- Small Molecule Insulin Sensitisers: New Leads and Targets for Next-Generation Insulin Sensitising Strategies.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026Review
- LRRC8A: A multifaceted regulator in cancer, neurological disorders, metabolic diseases and immune modulation.Genes & diseases · 2026Review
- Mechanism of action of two potent LRRC8/VRAC channel inhibitors.Research square · 2026Article
- Systemic effects of type 2 diabetes therapies: an integrated perspective on the cardio-renal- cerebral-metabolic axis.Frontiers in medicine · 2026Review
- A conserved mechanism of LRRC8 channel inhibition by two structurally distinct drugs.Communications biology · 2025Article
- Lysosomal LRRC8 complex impacts lysosomal pH, morphology, and systemic glucose metabolism.Science advances · 2025Article
- LRRC8 complexes are ATP release channels that regulate platelet activation and arterial thrombosis.Blood · 2025Article
- A large-scale curated and filterable dataset for cryo-EM foundation model pre-training.Scientific data · 2025Article
- A novel fullerene-lysine derivative with noticeable ROS scavenging capabilities for improving type 2 diabetes mellitus.Nanoscale advances · 2025Article
- Article
- Recent insights on the impact of SWELL1 on metabolic syndromes.Frontiers in pharmacology · 2025Review
- Regulation of volume-regulated anion channels alters sensitivity to platinum chemotherapy.Science advances · 2024Article
- Exploring the design of clinical research studies on the efficacy mechanisms in type 2 diabetes mellitus.Frontiers in endocrinology · 2024Review
- Physiological Functions of the Volume-Regulated Anion Channel VRAC/LRRC8 and the Proton-Activated Chloride Channel ASOR/TMEM206.Handbook of experimental pharmacology · 2024Article
- Mechanosensing in Metabolism.Comprehensive Physiology · 2023Review
Corrections and comments
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Authors and funding
30 authors at 6 institutions in 2 countries.
Susheel K Gunasekar *Department of Internal Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, USA.
Litao Xie *Department of Internal Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, USA.
Ashutosh Kumar *Department of Internal Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, USA.
Juan HongDepartment of Internal Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, USA.
Pratik R ChhedaDepartment of Pharmaceutical Sciences and Experimental Therapeutics, University of Iowa, College of Pharmacy, Iowa City, IA, USA.ORCID http://orcid.org/0000-0001-5788-3324
Chen KangDepartment of Internal Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, USA.
David M KernDepartment of Molecular & Cell Biology, University of California Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0000-0001-8529-9045
Chau My-TaFeinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Joshua MaurerDepartment of Internal Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, USA.
John HeebinkDepartment of Internal Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, USA.
Eva E GerberDepartment of Molecular & Cell Biology, University of California Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0000-0002-1862-3586
Wojciech J GrzesikStead Family Department of Pediatrics, Endocrinology and Diabetes Division, Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, IA, USA.
Macaulay Elliot-HudsonDepartment of Internal Medicine, Cardiovascular Division, University of Iowa, Iowa City, IA, USA.
Yanhui ZhangXiamen Cardiovascular Hospital, Xiamen University, Xiamen, China.
Phillip KeyDepartment of Internal Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, USA.
Chaitanya A KulkarniDepartment of Pharmaceutical Sciences and Experimental Therapeutics, University of Iowa, College of Pharmacy, Iowa City, IA, USA.
Joseph W BealsCenter for Human Nutrition, Washington University School of Medicine, St. Louis, USA.
Gordon I SmithCenter for Human Nutrition, Washington University School of Medicine, St. Louis, USA.
Isaac SamuelDepartment of Surgery, University of Iowa, Carver College of Medicine, Iowa City, IA, USA.
Jessica K SmithDepartment of Surgery, University of Iowa, Carver College of Medicine, Iowa City, IA, USA.
Peter NauDepartment of Surgery, University of Iowa, Carver College of Medicine, Iowa City, IA, USA.
Yumi ImaiDepartment of Internal Medicine, Cardiovascular Division, University of Iowa, Iowa City, IA, USA.
Ryan D SheldonDepartment of Biochemistry, University of Iowa, Iowa City, IA, USA.
Eric B TaylorDepartment of Biochemistry, University of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0003-4549-6567
Daniel J LernerSenseion Therapeutics Inc, BioGenerator Labs, St Louis, MO, USA.
Andrew W NorrisStead Family Department of Pediatrics, Endocrinology and Diabetes Division, Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0001-8396-9543
Samuel KleinCenter for Human Nutrition, Washington University School of Medicine, St. Louis, USA.
Stephen G BrohawnDepartment of Molecular & Cell Biology, University of California Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0000-0001-6768-3406
Robert KernsDepartment of Pharmaceutical Sciences and Experimental Therapeutics, University of Iowa, College of Pharmacy, Iowa City, IA, USA.ORCID http://orcid.org/0000-0001-5371-403X
Rajan SahDepartment of Internal Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, USA. rajan.sah@wustl.edu.ORCID http://orcid.org/0000-0003-1092-1244
Washington University in St. Louis · USUniversity of Iowa · USUniversity of California, Berkeley · USFraternal Order of Eagles · USFirst Affiliated Hospital of Xiamen University · CNNorthwestern University · US
Funding
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MViral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0MWashington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4MVector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5MWashington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2MWU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1MResource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2019 to 2026
$6.8MPROGRAM IN HEMOSTASIS AND THROMBOSIS FOR ACADEMICT32HL007344 · NHLBI · UNIVERSITY OF IOWA · PI Anil Kumar Chauhan, Steven R Lentz · 1985 to 2026
$6.5MRole of Lipid Droplet Proteins in Islet Function in Diabetes and ObesityR01DK090490 · NIDDK · UNIVERSITY OF IOWA · PI IMAI, YUMI · 2011 to 2025
$5.0MWUSTL Transdisciplinary Pre- and Postdoctoral Training Program in Obesity and Cardiovascular DiseaseT32HL130357 · NHLBI · WASHINGTON UNIVERSITY · PI WILFLEY, DENISE ELLA · 2016 to 2025
$4.3MPREDOCTORAL TRAINING PROGRAM IN BIOTECHNOLOGYT32GM008365 · NIGMS · UNIVERSITY OF IOWA · PI KERNS, ROBERT JOHN · 1990 to 2021
$3.8MTuning fat cell size and obesity through SWELL1R01DK106009 · NIDDK · WASHINGTON UNIVERSITY · PI SAH, RAJAN · 2016 to 2024
$3.8MBLRD VA I01 BX005072NCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA086862NHLBI NIH HHS T32 HL007344NHLBI NIH HHS T32 HL130357NIAMS NIH HHS P30 AR074992NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK054759NIDDK NIH HHS P30 DK056341NIDDK NIH HHS R01 DK090490NIDDK NIH HHS R01 DK106009NIDDK NIH HHS R01 DK115791NIDDK NIH HHS R01 DK126068NIDDK NIH HHS R01 DK127080NIDDK NIH HHS R43 DK121598NIDDK NIH HHS R44 DK121598NIDDK NIH HHS R44 DK126600NIGMS NIH HHS DP2 GM123496NIGMS NIH HHS F32 GM128263NIGMS NIH HHS T32 GM008365
Abstract
Type 2 diabetes is associated with insulin resistance, impaired pancreatic β-cell insulin secretion, and nonalcoholic fatty liver disease. Tissue-specific SWELL1 ablation impairs insulin signaling in adipose, skeletal muscle, and endothelium, and impairs β-cell insulin secretion and glycemic control. Here, we show that I
Indexed as
Adipose TissueAnimalsCryoelectron MicroscopyDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2GlucoseGlycemic ControlInsulinInsulin ResistanceInsulin-Secreting CellsInsulin SecretionLiverMaleMembrane ProteinsMiceMice, Inbred C57BLGlucoseInsulinLRRC8A protein, mouseMembrane Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.