ArticleCell death & disease2022
Genetic and pharmacological inhibition of XBP1 protects against APAP hepatotoxicity through the activation of autophagy.
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Article in Cell death & disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17citing papers in PubMed
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Phospholipid phosphatase 2 drives liver repair and regeneration after acute liver injury.Signal transduction and targeted therapy · 2026Article
- Edible Fungus Compound Cordycepin Protects Against Acetaminophen-Induced Liver Injury.Journal of clinical laboratory analysis · 2026Article
- Nimbolide Targeting SIRT1 Protects Against Acetaminophen-Induced Acute Liver Injury by Regulating Oxidative Stress and Endoplasmic Reticulum Stress.Pharmacology research & perspectives · 2025Article
- Roles of X-box binding protein 1 in liver pathogenesis.Clinical and molecular hepatology · 2025Review
- Human adenovirus type 7 (HAdV-7) infection induces pulmonary vascular endothelial injury through the activation of endothelial autophagy.Respiratory research · 2024Article
- Preserving mitochondrial homeostasis protects against drug-induced liver injury via inducing OPTN (optineurin)-dependent Mitophagy.Autophagy · 2024Article
- Neutrophil extracellular traps promote acetaminophen-induced acute liver injury in mice via AIM2.Acta pharmacologica Sinica · 2024Article
- Comparative analysis of gene expression between mice and humans in acetaminophen-induced liver injury by integrating bioinformatics analysis.BMC medical genomics · 2024Article
- Cell Death in Liver Disease and Liver Surgery.Biomedicines · 2024Review
- ARRB1 downregulates acetaminophen-induced hepatoxicity through binding to p-eIF2α to inhibit ER stress signaling.Cell biology and toxicology · 2024Article
- Involvement of autophagy in mesaconitine-induced neurotoxicity in HT22 cells revealed through integrated transcriptomic, proteomic, and m6A epitranscriptomic profiling.Frontiers in pharmacology · 2024Article
- Effects of toxicants on endoplasmic reticulum stress and hepatic cell fate determination.Toxicological research · 2023Review
- Geometric Isomer of Guanabenz Confers Hepatoprotection to a Murine Model of Acetaminophen Toxicity.Chemical research in toxicology · 2023Article
- Nuciferine Effectively Protects Mice against Acetaminophen-Induced Liver Injury.Antioxidants (Basel, Switzerland) · 2023Article
- Sirtuin 1 activator alleviated lethal inflammatory injuryFrontiers in pharmacology · 2023Article
- Nanomedicine Strategies for Heating "Cold" Ovarian Cancer (OC): Next Evolution in Immunotherapy of OC.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Autophagy, a novel player in acetaminophen (APAP)-induced hepatotoxicity.Autophagy reports · 2022Article
Corrections and comments
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Authors and funding
23 authors at 10 institutions in 6 countries.
Hui Ye *Department of Immunology, Ophthalmology and ENT, Complutense University School of Medicine, 28040, Madrid, Spain.
Chaobo Chen *Department of Immunology, Ophthalmology and ENT, Complutense University School of Medicine, 28040, Madrid, Spain.
Hanghang Wu *Department of Immunology, Ophthalmology and ENT, Complutense University School of Medicine, 28040, Madrid, Spain.
Kang ZhengDepartment of Immunology, Ophthalmology and ENT, Complutense University School of Medicine, 28040, Madrid, Spain.
Beatriz Martín-AdradosDepartment of Immunology, Ophthalmology and ENT, Complutense University School of Medicine, 28040, Madrid, Spain.
Esther CaparrosDepartmento de Medicina Clínica, Universidad Miguel Hernández, 03550, San Juan de Alicante, Spain.
Rubén FrancésDepartmento de Medicina Clínica, Universidad Miguel Hernández, 03550, San Juan de Alicante, Spain.
Leonard J NelsonInstitute for Bioengineering (IBioE), Human Tissue Engineering, Faraday Building, The University of Edinburgh, EH9 3DW, Edinburgh, Scotland, UK.
Manuel Gómez Del MoralDepartment of Cell Biology, Complutense University School of Medicine, 28040, Madrid, Spain.
Iris AsensioCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), 28029, Madrid, Spain.
Javier VaqueroCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), 28029, Madrid, Spain.
Rafael BañaresCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), 28029, Madrid, Spain.
Matías A ÁvilaCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), 28029, Madrid, Spain.
Raúl J AndradeCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), 28029, Madrid, Spain.
M Isabel LucenaCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), 28029, Madrid, Spain.
Maria Luz Martínez-ChantarCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), 28029, Madrid, Spain.ORCID 0000-0002-6446-9911
Helen L ReevesThe Liver Unit, Newcastle-upon-Tyne Hospitals NHS Foundation Trust, NE7 DN, Newcastle upon Tyne, UK.ORCID 0000-0003-0359-9795
Steven MassonThe Liver Unit, Newcastle-upon-Tyne Hospitals NHS Foundation Trust, NE7 DN, Newcastle upon Tyne, UK.ORCID 0000-0003-1041-9844
Richard S BlumbergDivision of Gastroenterology, Hepatology, and Endoscopy, Department of Medicine, Brigham and Women´s Hospital, Harvard Medical School, Boston, and Harvard Digestive Diseases Center, 02115, Boston, MA, USA.ORCID 0000-0002-9704-248X
Jordi Gracia-SanchoCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), 28029, Madrid, Spain.ORCID 0000-0001-7736-4089
Yulia A NevzorovaDepartment of Immunology, Ophthalmology and ENT, Complutense University School of Medicine, 28040, Madrid, Spain.
Eduardo Martínez-NavesDepartment of Immunology, Ophthalmology and ENT, Complutense University School of Medicine, 28040, Madrid, Spain.
Francisco Javier CuberoDepartment of Immunology, Ophthalmology and ENT, Complutense University School of Medicine, 28040, Madrid, Spain. fcubero@ucm.es.ORCID 0000-0003-1499-650X
Universidad Complutense de Madrid · ESHospital General Universitario Gregorio Marañón · ESCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas · ESNewcastle upon Tyne Hospitals NHS Foundation Trust · GBUniversitat de Miguel Hernández d'Elx · ESBrigham and Women's Hospital · USCIC bioGUNE · ESNavarre Institute of Health Research · ESUniversity of Bern · CHUniversity of Edinburgh · GB
Funding
Endoplasmic reticulum stress and intestinal inflammationR01DK088199 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI Richard S Blumberg · 2010 to 2026
$9.6MBiotechnology and Biological Sciences Research Council BB/L023687/1Cancer Research UK 23390Cancer Research UK 26813NIDDK NIH HHS R01 DK088199
Abstract
Acetaminophen (APAP) hepatotoxicity induces endoplasmic reticulum (ER) stress which triggers the unfolded protein response (UPR) in hepatocytes. However, the mechanisms underlying ER stress remain poorly understood, thus reducing the options for exploring new pharmacological therapies for patients with hyperacute liver injury. Eight-to-twelve-week-old C57BL/6J Xbp1-floxed (Xbp1
Indexed as
AcetaminophenChemical and Drug Induced Liver InjuryX-Box Binding Protein 1AnimalsAutophagyCytochrome P-450 CYP2E1HepatocytesHumansLiverMiceMice, Inbred C57BLMice, KnockoutAcetaminophenCytochrome P-450 CYP2E1X-Box Binding Protein 1Xbp1 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.