Evidence map›Paper›PMID 35145048›Full record

ArticleFolia parasitologica2022

Impact of chemoprophylaxis immunisation under halofantrine (CPS-HF) drug cover in Plasmodium yoelii Swiss mice malaria model.

Arif Jamal Siddiqui, Jyoti Bhardwaj, Walid Sabri Hamadou, Manish Goyal, Sadaf Jahan, Syed Amir Ashraf, Arshad Jamal, Pankaj Sharma, Manojkumar Sachidanandan, Riadh Badraoui and 2 more

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Article in Folia parasitologica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Host-parasite interactions duringFrontiers in immunology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Arif Jamal SiddiquiDepartment of Biology, College of Science, University of Hail, Hail, Saudi Arabia.ORCID 0000000262360920
Jyoti BhardwajIndiana University, School of Medicine, Indianapolis, Indiana, United States.
Walid Sabri HamadouDepartment of Biology, College of Science, University of Hail, Hail, Saudi Arabia.
Manish GoyalMolecular Parasitology and Immunology Division, CSIR-Central Drug Research Institute, Lucknow, India.
Sadaf JahanDepartment of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Al Majmaah, Saudi Arabia.
Syed Amir AshrafDepartment of Clinical Nutrition, College of Applied Medial Sciences, University of Hail, Hail, Saudi Arabia.
Arshad JamalDepartment of Biology, College of Science, University of Hail, Hail, Saudi Arabia.
Pankaj SharmaMolecular Parasitology and Immunology Division, CSIR-Central Drug Research Institute, Lucknow, India.
Manojkumar SachidanandanDepartment of Oral Radiology, College of Dentistry, University of Hail, Hail, Saudi Arabia.
Riadh BadraouiDepartment of Biology, College of Science, University of Hail, Hail, Saudi Arabia.
Mejdi SnoussiDepartment of Biology, College of Science, University of Hail, Hail, Saudi Arabia.
Mohd AdnanDepartment of Biology, College of Science, University of Hail, Hail, Saudi Arabia.ORCID 0000000270806822

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the present study, we have investigated the role of antimalarial drug halofantrine (HF) in inducing the sterile protection against challenges with sporozoites of the live infectious Plasmodium yoelii (Killick-Kendrick, 1967) in Swiss mice malaria model. We observed that during the first to third sequential sporozoite inoculation cycles, blood-stage patency remains the same in the control and chemoprophylaxis under HF drug cover (CPS-HF) groups. However, a delayed blood-stage infection was observed during the fourth and fifth sporozoite challenges and complete sterile protection was produced following the sixth sporozoite challenge in CPS-HF mice. We also noticed a steady decline in liver stage parasite load after 3th to 6th sporozoite challenge cycle in CPS-HF mice. CPS-HF immunisation results in a significant up-regulation of pro-inflammatory cytokines (IFN-γ, TNF-α, IL-12 and iNOS) and down-regulation of anti-inflammatory cytokines (IL-10 and TGF-β) mRNA expression in hepatic mononuclear cells (HMNC) and spleen cells in the immunised CPS-HF mice (after 6th sporozoite challenge) compared to control. Overall, our study suggests that the repetitive sporozoite inoculation under HF drug treatment develops a strong immune response that confers protection against subsequent challenges with sporozoites of P. yoelii.

Indexed as

MalariaPharmaceutical PreparationsPlasmodium yoeliiAnimalsChemopreventionImmunizationMiceMice, Inbred BALB CPhenanthreneshalofantrinePharmaceutical PreparationsPhenanthrenesCPS-immunisationcytokinesmRNA expressionReal Time PCRsporozoites

Identifiers

PMID35145048

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.