Evidence map›Paper›PMID 35144989›Full record

Trial reportThe European respiratory journal2022

Add-on inhaled budesonide in the treatment of hospitalised patients with COVID-19: a randomised clinical trial.

Alvar Agustí, Gaston De Stefano, Alberto Levi, Xavier Muñoz, Christian Romero-Mesones, Oriol Sibila, Alejandra Lopez-Giraldo, Vicente Plaza Moral, Elena Curto, Andrés L Echazarreta and 11 more

Registry-linked trialOpen access · hybridAbstract readLetterRandomized Controlled Trial
In one paragraph

Trial report in The European respiratory journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05855395 (A Bidimensional Early Intervention Strategy of Standard of Care Combined With Host Immunomodulation in Elderly Patients With Mild or Moderate COVID-19), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05855395 naunknown statusnot on this mapstarted 2023, after this paper: background citation

A Bidimensional Early Intervention Strategy of Standard of Care Combined With Host Immunomodulation in Elderly Patients With Mild or Moderate COVID-19: A Multicentre, Randomized, Controlled, Adaptive Platform Study

TypeinterventionalSponsorHuashan HospitalRan2023 to 2024Enrolled5,815ConditionsCOVID-19ArmsGlucocorticoid
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. The development of COVID-19 treatment.Frontiers in immunology · 2023
    Review
  9. Inhaled corticosteroids for the treatment of COVID-19.European respiratory review : an official journal of the European Respiratory Society · 2022
    Review
  10. European society of clinical microbiology and infectious diseases guidelines for coronavirus disease 2019: an update on treatment of patients with mild/moderate disease.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2022
    Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 10 institutions in 2 countries.

Alvar AgustíHospital Clinic, Barcelona, Spain aagusti@clinic.cat.
Gaston De StefanoServicio de Neumotisiologia, Hospital Francisco Muñiz, Buenos Aires, Argentina.
Alberto LeviServicio de Neumotisiologia, Hospital Francisco Muñiz, Buenos Aires, Argentina.ORCID 0000-0002-3886-2373
Xavier MuñozCIBER Enfermedades Respiratorias, Spain.
Christian Romero-MesonesCIBER Enfermedades Respiratorias, Spain.
Oriol SibilaHospital Clinic, Barcelona, Spain.
Alejandra Lopez-GiraldoUniversitat Barcelona, Barcelona, Spain.
Vicente Plaza MoralCIBER Enfermedades Respiratorias, Spain.ORCID 0000-0003-2567-5496
Elena CurtoCIBER Enfermedades Respiratorias, Spain.ORCID 0000-0002-7291-0543
Andrés L EchazarretaServicio de Neumonología, Hospital San Juan de Dios de La Plata, Buenos Aires, Argentina.ORCID 0000-0003-4997-5768
Silvana E MárquezServicio de Neumonología, Hospital San Juan de Dios de La Plata, Buenos Aires, Argentina.
Sergi Pascual-GuàrdiaCIBER Enfermedades Respiratorias, Spain.
Salud SantosUniversitat Barcelona, Barcelona, Spain.
Alicia MarinCIBER Enfermedades Respiratorias, Spain.ORCID 0000-0002-9358-2120
Luis ValdésServicio de Neumología, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain.
Fernando SaldariniSección de Neumotisiologia, Hospital Donación Francisco Santojanni, Buenos Aires, Argentina.ORCID 0000-0003-0337-2443
Clara SalgadoCentro de Educación Médica e Investigaciones Clínicas Norberto Quirno, Buenos Aires, Argentina.
Georgina CasanovasHospital Clinic, Barcelona, Spain.
Sara VareaHospital Clinic, Barcelona, Spain.
José RíosHospital Clinic, Barcelona, Spain.
Rosa FanerUniversitat Barcelona, Barcelona, Spain.
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias · ESUniversitat Autònoma de Barcelona · ESHospital Clínic de Barcelona · ESHospital Italiano La Plata · ARHospital Muñiz · ARBellvitge University Hospital · ESCentro de Educación Médica e Investigaciones Clínicas Norberto Quirno · ARHospital Donación Francisco Santojanni · ARUniversidade de Santiago de Compostela · ESUniversitat Pompeu Fabra · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

BudesonideCOVID-19Administration, InhalationBronchodilator AgentsDouble-Blind MethodGlucocorticoidsHumansSARS-CoV-2Bronchodilator AgentsBudesonideGlucocorticoids

Identifiers

PMID35144989
PMCPMC8832375
OpenAlexW4211245022

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.