Evidence map›Paper›PMID 35144965›Full record

ArticleGenes & development2022

Distinct structural bases for sequence-specific DNA binding by mammalian BEN domain proteins.

Luqian Zheng, Jingjing Liu, Lijie Niu, Mohammad Kamran, Ally W H Yang, Arttu Jolma, Qi Dai, Timothy R Hughes, Dinshaw J Patel, Long Zhang and 4 more

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Nacc1 Mutation in Mice Models Rare Neurodevelopmental Disorder with Underlying Synaptic Dysfunction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  9. Article
  10. BENDing with Polycomb in pluripotency and cancer.BioEssays : news and reviews in molecular, cellular and developmental biology · 2023
    Article
  11. Review
  12. Article
  13. Article
  14. BEND3 takes the rein.Science China. Life sciences · 2023
    Article
  15. Article
  16. AlphaFold2 and its applications in the fields of biology and medicine.Signal transduction and targeted therapy · 2023
    Review
  17. Article
  18. BEND3 safeguards pluripotency by repressing differentiation-associated genes.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Luqian Zheng *The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, Guangdong 518033, China.
Jingjing Liu *State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China.
Lijie NiuState Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China.
Mohammad KamranDepartment of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Ally W H YangDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A1, Canada.
Arttu JolmaDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A1, Canada.
Qi DaiDevelopmental Biology Program, Sloan Kettering Institute, New York, New York 10065, USA.ORCID 0000-0002-2082-0693
Timothy R HughesDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A1, Canada.ORCID 0000-0002-8721-4719
Dinshaw J PatelStructural Biology Program, Sloan Kettering Institute, New York, New York 10065, USA.
Long ZhangThe Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, Guangdong 518033, China.
Supriya G PrasanthDepartment of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Yang YuState Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China.
Aiming RenLife Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Eric C LaiDevelopmental Biology Program, Sloan Kettering Institute, New York, New York 10065, USA.ORCID 0000-0002-8432-5851
Chinese Academy of Medical Sciences & Peking Union Medical College · CNKettering University · USUniversity of Toronto · CASun Yat-sen University · CNUniversity of Illinois Urbana-Champaign · USZhejiang University · CN

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Selective regulatory and biogenesis mechanisms for microRNAsR01GM083300 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI Eric C Lai · 2007 to 2026
$9.8M
Mechanism and regulation of Hu family RNA binding proteins during neural alternative polyadenylationR01NS083833 · NINDS · SLOAN-KETTERING INST CAN RESEARCH · PI LAI, ERIC C · 2014 to 2023
$5.4M
BEN factors are conserved CSL co-repressors in Notch-mediated neural developmentR01NS074037 · NINDS · SLOAN-KETTERING INST CAN RESEARCH · PI LAI, ERIC C · 2011 to 2015
$2.1M
Regulation of genomic stability by ORCR01GM125196 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI PRASANTH, SUPRIYA G · 2018 to 2021
$1.3M
NCI NIH HHS P30 CA008748NIGMS NIH HHS R01 GM083300NIGMS NIH HHS R01 GM125196NINDS NIH HHS R01 NS074037NINDS NIH HHS R01 NS083833
6 · The paper itself

Abstract

The BEN domain is a recently recognized DNA binding module that is present in diverse metazoans and certain viruses. Several BEN domain factors are known as transcriptional repressors, but, overall, relatively little is known of how BEN factors identify their targets in humans. In particular, X-ray structures of BEN domain:DNA complexes are only known for

Indexed as

Repressor ProteinsTranscription FactorsAnimalsBinding SitesDrosophilaMammalsProtein BindingProtein DomainsRepressor ProteinsTranscription FactorsDNA binding activitygene regulationprotein–DNA structuretranscription factor

Identifiers

PMID35144965
PMCPMC8887127
OpenAlexW4211062370

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.