Evidence map›Paper›PMID 35144939›Full record

ArticleBMJ open diabetes research & care2022

Emily M Russell, Jenna C Carlson, Mohanraj Krishnan, Nicola L Hawley, Guangyun Sun, Hong Cheng, Take Naseri, Muagututi'a Sefuiva Reupena, Satupa'itea Viali, John Tuitele and 7 more

Open access · goldAbstract read
In one paragraph

Article in BMJ open diabetes research & care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
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  3. Review
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 4 countries.

Emily M RussellDepartment of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-9151-0310
Jenna C CarlsonDepartment of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, USA.
Mohanraj KrishnanDepartment of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, USA.
Nicola L HawleyDepartment of Chronic Disease Epidemiology, Yale University School of Public Health, New Haven, Connecticut, USA.
Guangyun SunDepartment of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Hong ChengDepartment of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Take NaseriMinistry of Health, Government of Samoa, Apia, Samoa.
Muagututi'a Sefuiva ReupenaLutia i Puava 'ae Mapu i Fagalele, Apia, Samoa.
Satupa'itea VialiSchool of Medicine, National University of Samoa, Apia, Samoa.
John TuiteleDepartment of Public Health, Lyndon B Johnson Tropical Medical Center, Faga'alu, American Samoa.
Tanya J MajorDepartment of Biochemistry, University of Otago, Dunedin, New Zealand.
Iva MiljkovicDepartment of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, USA.
Tony R MerrimanDepartment of Biochemistry, University of Otago, Dunedin, New Zealand.
Ranjan DekaDepartment of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Daniel E WeeksDepartment of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, USA.
Stephen T McGarveyInternational Health Institute and Department of Epidemiology, Brown University School of Public Health, Providence, Rhode Island, USA.
Ryan L MinsterDepartment of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, USA ryan.minster@pitt.edu.
University of Pittsburgh · USNational University of Samoa · WSUniversity of Cincinnati Medical Center · USBrown University · USLBJ Tropical Medical Center · ASUniversity of Alabama at Birmingham · USUniversity of Otago · NZYale University · US

Funding

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI PINNEY, SUSAN MENGEL · 1992 to 2022
$35.4M
Integrated cellular, mouse and human research on a novel missense variant influencing adiposity in SamoansR01HL093093 · NHLBI · BROWN UNIVERSITY · PI MCGARVEY, STEPHEN T. · 2009 to 2019
$8.2M
Next Generation Association Studies of Adiposity in Samoans Enhanced by a Samoan-Specific Whole Genome Sequence Reference PanelR01HL133040 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Ryan Lee Minster · 2017 to 2026
$7.5M
GENOME SCAN FOR OBESITY SUSCEPTIBILITY LOCI IN SAMOANSR01DK059642 · NIDDK · BROWN UNIVERSITY · PI MCGARVEY, STEPHEN T. · 2000 to 2004
$2.6M
GENOME SCAN FOR NIDDM SUSCEPTIBILITY GENES AMONG SAMOANSR01DK055406 · NIDDK · UNIVERSITY OF CINCINNATI · PI DEKA, RANJAN · 1998 to 2002
$664k
GENETICS OF CVD RISK FACTORS IN SAMOANSR01HL052611 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAMBOH, M. ILYAS · 1995 to 1998
–
ADIPOSITY INSULIN ELECTROLYTES AND SAMOAN BLOOD PRESSURER01AG009375 · NIA · MIRIAM HOSPITAL · PI MCGARVEY, STEPHEN T. · 1990 to 1994
–
NHLBI NIH HHS R01 HL052611NHLBI NIH HHS R01 HL093093NHLBI NIH HHS R01 HL133040NIA NIH HHS R01 AG009375NIDDK NIH HHS R01 DK055406NIDDK NIH HHS R01 DK059642NIEHS NIH HHS P30 ES006096
6 · The paper itself

Abstract

introductionThe minor allele of a missense variant, rs373863828, in RESEARCH DESIGN AND

methodsWe regressed type 2 diabetes and fasting glucose on BMI and rs373863828 stratified by obesity, regressed type 2 diabetes and fasting glucose on BMI stratified by rs373863828 genotype, and assessed the effects of rs373863828 on type 2 diabetes and fasting glucose with path analysis. The regression analyses were completed separately in four samples that were recruited during different time periods between 1990 and 2010 and then the results were meta-analyzed. All samples were pooled for the path analysis.

resultsAssociation of BMI with type 2 diabetes and fasting glucose may be greater in those without obesity (OR=7.77, p=0.015 and β=0.213, p

conclusionsThere may be a stronger effect of BMI on fasting glucose in Polynesian individuals without obesity than in those with obesity. Carrying the rs373863828 minor allele does not decouple higher BMI from higher odds of type 2 diabetes.

Indexed as

Diabetes Mellitus, Type 2AdultCross-Sectional StudiesFastingGlucoseHumansNew ZealandSamoaTumor Suppressor ProteinsGlucoseTumor Suppressor ProteinsBMIgeneticsglucoseobesity

Identifiers

PMID35144939
PMCPMC8845200
OpenAlexW4211185607

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.