ArticlePsychological medicine2023
Characterizing sustained social anxiety in individuals at clinical high risk for psychosis: trajectory, risk factors, and functional outcomes.
Article in Psychological medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- Examining clinical relevance of interpretation inflexibility in social contexts.Annals of general psychiatry · 2026Article
- Mentalizing impairments and hypermentalizing bias in individuals with first-episode schizophrenia-spectrum disorder and at-risk mental state: the differential roles of neurocognition and social anxiety.European archives of psychiatry and clinical neuroscience · 2025Article
- Fear and Anxiety in Schizophrenia: A Focus on Development, Assessment, and Mechanisms.Current topics in behavioral neurosciences · 2025Review
- Psychosis superspectrum I: Nosology, etiology, and lifespan development.Molecular psychiatry · 2024Review
- Psychological and social difficulties in young non-help-seeking adolescents at risk for psychosis: insights from a large cohort study.Frontiers in psychology · 2024Article
- Application of a virtual reality-based cognitive-behavioural therapy of social phobia in the treatment of inpatients diagnosed with schizophrenia and social anxiety - a feasibility study.Frontiers in psychiatry · 2024Article
- Skills program for awareness, connectedness, and empowerment: A conceptual framework of a skills group for individuals with a psychosis-risk syndrome.Frontiers in psychiatry · 2023Article
- The impact of COVID-19 pandemic on individuals at clinical high-risk for psychosis: Evidence from eye-tracking measures.Progress in neuro-psychopharmacology & biological psychiatry · 2022Article
- Cognitive functioning in a group of adolescents at risk for psychosis.Frontiers in psychiatry · 2022Article
- Unlocking the epigenome: Stress and exercise induced Bdnf regulation in the prefrontal cortex.Neurotoxicology and teratologyArticle
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Authors and funding
12 authors at 8 institutions in 2 countries.
Funding
Abstract
backgroundWhile comorbidity of clinical high-risk for psychosis (CHR-P) status and social anxiety is well-established, it remains unclear how social anxiety and positive symptoms covary over time in this population. The present study aimed to determine whether there are more than one covariant trajectory of social anxiety and positive symptoms in the North American Prodrome Longitudinal Study cohort (NAPLS 2) and, if so, to test whether the different trajectory subgroups differ in terms of genetic and environmental risk factors for psychotic disorders and general functional outcome.
methodsIn total, 764 CHR individuals were evaluated at baseline for social anxiety and psychosis risk symptom severity and followed up every 6 months for 2 years. Application of group-based multi-trajectory modeling discerned three subgroups based on the covariant trajectories of social anxiety and positive symptoms over 2 years.
resultsOne of the subgroups showed sustained social anxiety over time despite moderate recovery in positive symptoms, while the other two showed recovery of social anxiety below clinically significant thresholds, along with modest to moderate recovery in positive symptom severity. The trajectory group with sustained social anxiety had poorer long-term global functional outcomes than the other trajectory groups. In addition, compared with the other two trajectory groups, membership in the group with sustained social anxiety was predicted by higher levels of polygenic risk for schizophrenia and environmental stress exposures.
conclusionsTogether, these analyses indicate differential relevance of sustained
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