Evidence map›Paper›PMID 35144624›Full record

ArticleVirology journal2022

A UV-LED module that is highly effective at inactivating human coronaviruses and HIV-1.

Arvin T Persaud, Jonathan Burnie, Laxshaginee Thaya, Liann DSouza, Steven Martin, Christina Guzzo

Abstract read
In one paragraph

Article in Virology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Arvin T Persaud *Department of Biological Sciences, University of Toronto Scarborough, 1265 Military Trail, Room SW560, Toronto, ON, M1C 1A4, Canada.
Jonathan Burnie *Department of Biological Sciences, University of Toronto Scarborough, 1265 Military Trail, Room SW560, Toronto, ON, M1C 1A4, Canada.
Laxshaginee ThayaDepartment of Biological Sciences, University of Toronto Scarborough, 1265 Military Trail, Room SW560, Toronto, ON, M1C 1A4, Canada.
Liann DSouzaSafe Antiviral Technologies Inc, 822 Manning Ave, Toronto, ON, M6G 2W8, Canada.
Steven MartinSafe Antiviral Technologies Inc, 822 Manning Ave, Toronto, ON, M6G 2W8, Canada.
Christina GuzzoDepartment of Biological Sciences, University of Toronto Scarborough, 1265 Military Trail, Room SW560, Toronto, ON, M1C 1A4, Canada. christina.guzzo@utoronto.ca.ORCID 0000-0002-3042-0976

Funding

National Sciences and Engineering Research Council of Canada (NSERC) ALLRP 552685-2020National Sciences and Engineering Research Council of Canada (NSERC) RGPIN-2019-06442
6 · The paper itself

Abstract

Ultraviolet (UV) light has previously been established as useful method of disinfection, with demonstrated efficacy to inactivate a broad range of microorganisms. The advent of ultraviolet light-emitting diodes provides advantages in ease of disinfection, in that there can be delivery of germicidal UV with the same light unit that delivers standard white light to illuminate a room. Herein we demonstrate the efficacy and feasibility of ultraviolet light-emitting diodes as a means of decontamination by inactivating two distinct virus models, human coronavirus 229E and human immunodeficiency virus. Importantly, the same dose of ultraviolet light that inactivated human viruses also elicited complete inactivation of ultraviolet-resistant bacterial spores (Bacillus pumilus), a gold standard for demonstrating ultraviolet-mediated disinfection. This work demonstrates that seconds of ultraviolet light-emitting diodes (UV-LED) exposure can inactivate viruses and bacteria, highlighting that UV-LED could be a useful and practical tool for broad sanitization of public spaces.

Indexed as

Coronavirus 229E, HumanDisinfectionHIV-1Ultraviolet RaysHumansVirus InactivationBacillus pumilusHuman coronavirus (hCoV)Human immunodeficiency virus (HIV)Light emitting diode (LED)Ultraviolet light (UV)UV disinfectionUV sanitizationVirus inactivation

Identifiers

PMID35144624
PMCPMC8829982

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.