ArticleBMC emergency medicine2022
Nationwide improvements in geriatric mortality due to traumatic brain injury in Japan.
Article in BMC emergency medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 16 citations in OpenAlex.
- 25-Year experience with adult polytraumatized patients in a European level 1 trauma center: polytrauma between 1995 and 2019. What has changed? A retrospective cohort study.Archives of orthopaedic and trauma surgery · 2023Trial
- Sex and Age Differences in Outcomes of Traumatic Brain Injury: Findings from the Japan Neurotrauma Data Bank.Journal of clinical medicine · 2026Article
- A case of open skull fracture, subdural hematoma, and brain contusion complicated by traumatic brain injury-associated coagulopathy caused by a lawn trimmer; A case report.Trauma case reports · 2025Article
- Article
- Trends in isolated chest trauma in Japan: a 15-year analysis using the Japan Trauma Data Bank.Journal of thoracic disease · 2025Article
- Cellular Stem Cell Therapy for Treating Traumatic Brain Injury: Strategies for Enhancement of Therapeutic Efficacy.Molecular neurobiology · 2025Review
- A study of traumatic brain injury in Puerto Rico.The journal of the International Society of Physical and Rehabilitation Medicine · 2025Article
- Possible limited justification for systematic head computed tomography scans based solely on antithrombotic therapy in elderly patients (aged 75 or older) with mild traumatic brain injury.Research in diagnostic and interventional imaging · 2025Article
- Effect of low fibrinogen level on in-hospital mortality and 6-month functional outcome of TBI patients, a single center experience.Neurosurgical review · 2024Article
- Article
- Prediction of Mortality in Geriatric Traumatic Brain Injury Patients Using Machine Learning Algorithms.Brain sciences · 2023Article
- The Outcome of Neurorehabilitation Efficacy and Management of Traumatic Brain Injury.Frontiers in human neuroscience · 2022Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTraumatic brain injury (TBI), both isolated and in combination with extracranial lesions, is a global health problem associated with high mortality. Among various risk factors for poor clinical outcomes, age is the most important independent predictor of mortality in patients with TBI. TBI-related mortality is expected to increase as the society ages. However, in a super-aged society such as Japan, little is known about the trend of TBI-related mortality among older adults. Herein, we assessed the nationwide trend of the incidence and clinical outcomes of geriatric patients with TBI in Japan using the national Japanese Trauma Data Bank (JTDB) registry.
methodsIn this retrospective cohort study, cases of TBI (aged ≥65 years) in hospitals registered with the JTDB database between January 2004 and December 2018 were included. In-hospital mortality was the primary outcome, and mortality in the emergency department was the secondary outcome. The odds ratios (ORs) and 95% confidence intervals (CIs) for in-hospital deaths with respect to 3-year periods were assessed using multivariable analysis after adjusting for potential confounders.
resultsThe main cause of TBI in older individuals was falls. The proportion of patients who died after hospitalization during the study period decreased markedly from 29.5% (194/657) during 2004-2006 to 14.2% (1309/9240) during 2016-2018 in the isolated TBI group (adjusted OR = 0.42, 95% CI: 0.33-0.53) and from 48.0% (119/248) during 2004-2006 to 21.7% (689/3172) during 2016-2018 in the multiple trauma group (adjusted OR = 0.32, 95% CI: 0.23-0.45). The adjusted ORs for the 3-year increment were 0.84 (95% CI: 0.81-0.88) and 0.78 (95% CI: 0.75-0.83) for the isolated TBI and multiple trauma groups, respectively.
conclusionsUsing the national JTDB registry, we demonstrated a nationwide reduction in TBI-related mortality. Our findings in the super-aged society of Japan may provide insight for the treatment of geriatric patients with TBI worldwide.
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