Evidence map›Paper›PMID 35144503›Full record

ArticleJournal of diabetes science and technology2023

Intraperitoneal Insulin Delivery: Evidence of a Physiological Route for Artificial Pancreas From Compartmental Modeling.

Jorge Lo Presti, Alfonso Galderisi, Francis J Doyle, Howard C Zisser, Eyal Dassau, Eric Renard, Chiara Toffanin, Claudio Cobelli

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes science and technology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. APL bioengineering · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

Jorge Lo PrestiDepartment of Woman's and Child's Health, University of Padova, Padova, Italy.
Alfonso GalderisiDepartment of Woman's and Child's Health, University of Padova, Padova, Italy.ORCID 0000-0001-8885-3056
Francis J DoyleHarvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-3293-9114
Howard C ZisserDepartment of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, CA, USA.
Eyal DassauHarvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.
Eric RenardDepartment of Endocrinology, Diabetes, Nutrition and INSERM Clinical Investigation Center 1411, University Hospital of Montpellier, Montpellier, France.ORCID 0000-0002-3407-7263
Chiara ToffaninDepartment of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy.ORCID 0000-0003-1288-3456
Claudio CobelliDepartment of Woman's and Child's Health, University of Padova, Padova, Italy.ORCID 0000-0002-0169-6682
Harvard University · USUniversity of Padua · ITCentre National de la Recherche Scientifique · FRHôpital Necker-Enfants Malades · FRUniversity of California, Santa Barbara · USUniversity of Pavia · IT

Funding

Closed-loop Artificial Pancreas: Algorithm Engineering and Clinical EvaluationR01DK085628 · NIDDK · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI DOYLE, FRANCIS J, JOVANOVIC, LOIS · 2009 to 2013
$3.4M
An Implanted Intraperitoneal (IP-IP) Artificial Pancreas; a quantum leap forwardDP3DK101068 · NIDDK · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI ZISSER, HOWARD · 2013 to 2016
$2.6M
NIDDK NIH HHS DP3 DK101068NIDDK NIH HHS R01 DK085628
6 · The paper itself

Abstract

backgroundIntraperitoneal insulin delivery has proven to safely overcome a major limit of subcutaneous delivery-meal announcement-and has been able to optimize glycemic control in adults under controlled experimental conditions. In addition, intraperitoneal delivery avoids peripheral hyperinsulinemia resulting from the subcutaneous route and restores a physiological liver gradient.

methodsRelying on a unique data set of intraperitoneal closed-loop insulin delivery obtained with a Model Predictive Controller (MPC), we develop a compartmental model of intraperitoneal insulin kinetics, which, once included in the UVa/Padova T1D simulator, will facilitate the investigation of various control strategies, for example, the simpler Proportional Integral Derivative controller versus MPC.

resultsIntraperitoneal insulin kinetics can be described with a 2-compartment model including liver and plasma.

conclusionIntraperitoneal insulin transit is fast enough to render irrelevant the addition of a peritoneal compartment, proving the peritoneum being a virtual-not actual-transit space for insulin delivery.

Indexed as

Diabetes Mellitus, Type 1Pancreas, ArtificialAdultAlgorithmsBlood GlucoseEpidemiological ModelsHumansHypoglycemic AgentsInsulinInsulin Infusion SystemsInsulin, Regular, HumanBlood GlucoseHypoglycemic AgentsInsulinInsulin, Regular, Humanclosed-loopinsulin kineticsintraperitoneal insulin deliverytype 1 diabetes

Identifiers

PMID35144503
PMCPMC10210098
OpenAlexW4211240910

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.