ArticleNeuroImage2022
Cortical layer-specific differences in stimulus selectivity revealed with high-field fMRI and single-vessel resolution optical imaging of the primary visual cortex.
Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Bridging the gap with invasive imaging: promises and challenges of a new generation of ultrahigh resolution fMRI.bioRxiv : the preprint server for biology · 2026Article
- Measurement of electrochemical brain activity with fast-scan cyclic voltammetry during functional magnetic resonance imaging.Nature protocols · 2026Review
- Biophysical simulations of fMRI responses using realistic microvascular models: Insights into distinct hemodynamics in humans and mice.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Latent encoding of movement in primary visual cortex.bioRxiv : the preprint server for biology · 2025Article
- Differentiating BOLD and non-BOLD signals in fMRI time series using cross-cortical depth delay patterns.bioRxiv : the preprint server for biology · 2025Article
- Review
- Distal activity patterns shape the spatial specificity of neurovascular coupling.Nature neuroscience · 2024Article
- Article
- Imaging the columnar functional organization of human area MT+ to axis-of-motion stimuli using VASO at 7 Tesla.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- High fidelity sensory-evoked responses in neocortex after intravenous injection of genetically encoded calcium sensors.bioRxiv : the preprint server for biology · 2023Article
- High fidelity sensory-evoked responses in neocortex after intravenous injection of genetically encoded calcium sensors.Frontiers in neuroscience · 2023Article
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
The mammalian neocortex exhibits a stereotypical laminar organization, with feedforward inputs arriving primarily into layer 4, local computations shaping response selectivity in layers 2/3, and outputs to other brain areas emanating via layers 2/3, 5 and 6. It cannot be assumed a priori that these signatures of laminar differences in neuronal circuitry are reflected in hemodynamic signals that form the basis of functional magnetic resonance imaging (fMRI). Indeed, optical imaging of single-vessel functional responses has highlighted the potential limits of using vascular signals as surrogates for mapping the selectivity of neural responses. Therefore, before fMRI can be employed as an effective tool for studying critical aspects of laminar processing, validation with single-vessel resolution is needed. The primary visual cortex (V1) in cats, with its precise neuronal functional micro-architecture, offers an ideal model system to examine laminar differences in stimulus selectivity across imaging modalities. Here we used cerebral blood volume weighted (wCBV) fMRI to examine if layer-specific orientation-selective responses could be detected in cat V1. We found orientation preference maps organized tangential to the cortical surface that typically extended across depth in a columnar fashion. We then examined arterial dilation and blood velocity responses to identical visual stimuli by using two- and three- photon optical imaging at single-vessel resolution-which provides a measure of the hemodynamic signals with the highest spatial resolution. Both fMRI and optical imaging revealed a consistent laminar response pattern in which orientation selectivity in cortical layer 4 was significantly lower compared to layer 2/3. This systematic change in selectivity across cortical layers has a clear underpinning in neural circuitry, particularly when comparing layer 4 to other cortical layers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.